ArticleClinical and diagnostic laboratory immunology2003
Detection of immunoglobulin M antibodies to hepatitis E virus by class capture enzyme immunoassay.
Article in Clinical and diagnostic laboratory immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors.Transfusion · 2014Trial
- [Laboratory diagnosis of hepatitis type E].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Laboratory Diagnosis of HEV Infection.Advances in experimental medicine and biology · 2023Review
- Immunobiology and Host Response to HEV.Advances in experimental medicine and biology · 2023Article
- Calibrating Hepatitis E Virus Serological Assays Using Asymptomatic Specimens Obtained in Japan.Microbiology spectrum · 2022Article
- Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.Clinical and translational gastroenterology · 2020Observational
- Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections.Cold Spring Harbor perspectives in medicine · 2019Review
- Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda.The Journal of infectious diseases · 2018Article
- The role of hepatitis E virus infection in adult Americans with acute liver failure.Hepatology (Baltimore, Md.) · 2016Observational
- Article
- The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh.The American journal of tropical medicine and hygiene · 2016Article
- An Epidemiologic Investigation of a Case of Acute Hepatitis E.Journal of clinical microbiology · 2015Article
- Autochthonous hepatitis e virus infections: a new transfusion-associated risk?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Review
- Diagnosis of hepatitis E.Nature reviews. Gastroenterology & hepatology · 2013Review
- A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture.The Journal of general virology · 2012Article
- Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.Gastroenterology · 2011Article
- Clinical significance of anti-HEV IgA in diagnosis of acute genotype 4 hepatitis E virus infection negative for anti-HEV IgM.Digestive diseases and sciences · 2009Article
- Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988-1994.The Journal of infectious diseases · 2009Article
- Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.Journal of immunological methods · 2007Article
- Comparison of a new immunochromatographic test to enzyme-linked immunosorbent assay for rapid detection of immunoglobulin m antibodies to hepatitis e virus in human sera.Clinical and diagnostic laboratory immunology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The measurement of antibodies to hepatitis E virus (anti-HEV) has been essential for understanding the epidemiology of hepatitis E. Studies to determine the prevalence of HEV infections require a reliable serologic assay that is sensitive and specific. It is also important to distinguish the acute from the convalescent phase of an infection; this usually requires the detection of the immunoglobulin M (IgM) class of antibody. Few enzyme immunoassays (EIAs) that measure IgM anti-HEV have been described, and most have utilized the sandwich method. The present study describes an EIA that detects IgM anti-HEV by antibody class capture methodology. The assay was validated by using serum and/or plasma panels from experimentally infected nonhuman primates. It was used to demonstrate an anamnestic response and the reappearance of IgM anti-HEV in a chimpanzee experimentally challenged with HEV at two different times 45 months apart. The class capture method was more sensitive than the sandwich EIA when used to test clinical samples from two hepatitis E epidemics in Pakistan; it also had the advantage of distinguishing IgM anti-HEV in the presence of high titers of IgG anti-HEV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.