ArticleAmerican journal of human genetics2003
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- The role of Wnt pathway in obesity induced inflammation and diabetes: a review.Journal of diabetes and metabolic disorders · 2021Review
- Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.Scientific reports · 2021Article
- The Role ofDiabetes · 2021Review
- Cervical Spine Malformations Associated With a 5q34-5q35.2 Micro-interstitial Deletion: A Case Report.Annals of rehabilitation medicine · 2018Article
- What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?Metabolic syndrome and related disorders · 2018Review
- Cord blood DNA methylation and adiposity measures in early and mid-childhood.Clinical epigenetics · 2017Article
- Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis.Genes & diseases · 2016Review
- Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.PLoS genetics · 2015Article
- Review
- Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon.Journal of diabetes and metabolic disorders · 2015Article
- Article
- Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion.Proceedings. Biological sciences · 2014Article
- Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.American journal of human genetics · 2014Article
- Genetic Testing and Type 2 Diabetes Risk Awareness.The Diabetes educator · 2014Article
- Programming of DNA methylation in type 2 diabetes.Diabetologia · 2013Article
- Article
- Overweight condition and waist circumference and a candidate gene within the 12q24 locus.Cardiovascular diabetology · 2013Article
- Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES).Human heredity · 2013Article
- From mice to humans.Current diabetes reports · 2012Review
3 more citing papers are in PubMed but not listed here.
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23 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic population. A list of type 2 diabetics was cross-matched with a computerized genealogical database clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives were genotyped with 906 microsatellite markers. A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 2.90, P=1.29 x 10(-4)) in all diabetics. Since obesity, here defined as body mass index (BMI) > or =30 kg/m(2), is a key risk factor for the development of T2D, we studied the data either independently of BMI or by stratifying the patient group as obese (BMI > or =30) or nonobese (BMI <30). A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 3.64, P=2.12 x (10)-5) in the nonobese diabetics. No linkage was observed in this region for the obese diabetics. Linkage analysis conditioning on maternal transmission to the nonobese diabetics resulted in a LOD score of 3.48 (P=3.12 x 10(-5)) in the same region, whereas conditioning on paternal transmission led to a substantial drop in the LOD score. Finally, we observed potential interactions between the 5q locus and two T2D susceptibility loci, previously mapped in other populations.
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