ArticleVirchows Archiv : an international journal of pathology2003
Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- An extremely rare case of thymic carcinoma manifesting as a liver metastasis: a case report and literature review.Discover oncology · 2025Article
- Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025Review
- Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.Virchows Archiv : an international journal of pathology · 2017Article
- Expression of p40 (∆Np63) protein in meningiomas, an unexpected finding: immunohistochemical study and evaluation of its possible prognostic role.Journal of neuro-oncology · 2016Article
- Prognostic value of immunohistochemical markers in malignant thymic epithelial tumors.Journal of thoracic disease · 2016Article
- The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Review
- Article
- Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry.Virchows Archiv : an international journal of pathology · 2013Article
- Absence of TCL1A expression is a useful diagnostic feature in splenic marginal zone lymphoma.Virchows Archiv : an international journal of pathology · 2012Article
- Insertion/deletion polymorphisms in the ΔNp63 promoter are a risk factor for bladder exstrophy epispadias complex.PLoS genetics · 2012Article
- Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings.The American journal of pathology · 2011Article
- DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.PloS one · 2010Article
- Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis.Respiratory research · 2006Article
- Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study.Journal of Korean medical science · 2006Article
- Expression of p63 in reactive hyperplasias and malignant lymphomas.Journal of Korean medical science · 2005Article
- Pattern of p63 expression in squamous cell carcinoma of the oral cavity.Virchows Archiv : an international journal of pathology · 2004Article
- Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p63, a member of the p53 family, is involved in the survival and differentiation of reserve/stem cells in different epithelia. To unveil the possible role of p63 in thymic physiology and pathology, we investigated the expression of p63 isoforms in normal thymus, thymomas and other mediastinal tumours. All samples were analysed using immunohistochemistry with three different antibodies: 4A4 antibody recognising all p63 isoforms, p40 antibody reacting only with truncated dominant-negative isoforms (DeltaN-p63) and H-129 antibody recognising all alpha-isoforms. Reverse-transcription polymerase chain reaction (RT-PCR), and real-time PCR analyses were performed on RNA extracted from frozen samples of four thymomas and two primary-mediastinal large-B-cell lymphoma (PMLBCL). In normal thymus, DeltaN-p63alpha was expressed in all cortical and medullary epithelial cells, with decreasing intensity in Hassall's corpuscles. This phenotype was conserved in neoplastic transformation since all 54 investigated thymomas (World Health Organization types A, AB, B1, B2, B3, C) expressed DeltaN-p63alpha (virtually 100% cells). The predominance of DeltaN-p63alpha isoform mRNA was confirmed by real-time PCR. Among other mediastinal tumours, DeltaN-p63alpha was only expressed in those displaying either a stratified epithelial component (teratomas) or epidermoid differentiation (lung carcinoma). Among lymphomas, T-cell-precursor lymphomas did not express p63, whereas most PMLBCL expressed TA-p63alpha (7/8).
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