Trial reportInternational urogynecology journal and pelvic floor dysfunction2003
A double-blind placebo-controlled trial on the effects of 25 mg estradiol implants on the urge syndrome in postmenopausal women.
Trial report in International urogynecology journal and pelvic floor dysfunction, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Oestrogen therapy for urinary incontinence in post-menopausal women.The Cochrane database of systematic reviews · 2012Pooled it
- Incontinence-specific quality of life measures used in trials of treatments for female urinary incontinence: a systematic review.International urogynecology journal and pelvic floor dysfunction · 2006Pooled it
- The effect of ultralow-dose transdermal estradiol on urinary incontinence in postmenopausal women.Obstetrics and gynecology · 2005Trial
- Subcutaneous Estradiol Pellets as Hormone Therapy in Menopause: Clinical Pharmacology, Patient Selection and Safety Considerations.Journal of clinical medicine · 2025Review
- Innovative Drug Delivery Systems for Management of Menopausal Symptoms: A Systematic Review.International journal of women's health · 2025Review
- Does estrogen have any real effect on voiding dysfunction in women?Current urology reports · 2011Review
- Risk of urinary incontinence symptoms in oral contraceptive users: a national cohort study from the Swedish Twin Register.Fertility and sterility · 2009Article
- Hormone replacement therapy has no routine role in the management of postmenopausal voiding dysfunction.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2009Article
- Estrogen therapy and urinary incontinence: what is the evidence and what do we tell our patients?International urogynecology journal and pelvic floor dysfunction · 2006Review
- Menopause hormonal therapy from the urologist's perspective.Current urology reports · 2006Article
- Influence of estradiol on micturition thresholds in the rat: involvement of the hypogastric nerve.American journal of physiology. Regulatory, integrative and comparative physiology · 2005Article
- Estrogen for overactive bladder and patient perception of incontinence.Reviews in urology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this prospective double-blind randomized placebo-controlled trial was to determine the effect of systemic estrogen on the 'urge syndrome' in postmenopausal women. The trial took place in a tertiary referral urogynecology unit. Postmenopausal women with the 'urge syndrome' were randomly allocated to receive a 25 mg 17beta-estradiol implant or placebo implant. Serum estradiol levels and endometrial thickness were measured on entry to the trial and at 1, 3 and 6 months. The following outcome measures were employed: videocystourethrography, frequency volume chart, visual analogue score of symptoms, and King's Health Care Quality of life Questionnaire. Forty women were included. Subjectively there was a significant improvement in urgency in both groups and urge incontinence in the estradiol group, but no significant differences between the groups. Objectively no significant differences were demonstrated between the groups. Nine women in the estradiol group had vaginal bleeding, and 5 had a hysterectomy during or after the study. Despite using numerous outcome measures to examine its effect, 25 mg estradiol implants did not produce a greater improvement in the 'urge syndrome' than placebo and had a high complication rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.