ArticleProceedings of the National Academy of Sciences of the United States of America2003
What drives the translocation of stiff chains?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Trajectory Statistics of Biological Exploratory Dynamics.bioRxiv : the preprint server for biology · 2026Article
- Kinetic Description of Viral Capsid Self-Assembly Using Mesoscopic Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses.Sub-cellular biochemistry · 2024Review
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Experimental study of a nanoscale translocation ratchet.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cross-linkers at growing microtubule ends generate forces that drive actin transport.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pore shapes effects on polymer translocation.The European physical journal. E, Soft matter · 2020Article
- Polymer Translocation Across a Corrugated Channel: Fick⁻Jacobs Approximation Extended Beyond the Mean First-Passage Time.Polymers · 2019Article
- Ratchet rectification effect on the translocation of a flexible polyelectrolyte chain.The Journal of chemical physics · 2016Article
- A Brownian ratchet for protein translocation including dissociation of ratcheting sites.Journal of mathematical biology · 2013Article
- A single-molecule Hershey-Chase experiment.Current biology : CB · 2012Article
- Cooperative translocation dynamics of biopolymer chains through nanopores in a membrane: Slow dynamics limit.The European physical journal. E, Soft matter · 2010Article
- Polymer translocation in a double-force arrangement.The European physical journal. E, Soft matter · 2009Article
- Ejection dynamics of polymeric chains from viral capsids: effect of solvent quality.Biophysical journal · 2008Article
- Viral capsids: mechanical characteristics, genome packaging and delivery mechanisms.Cellular and molecular life sciences : CMLS · 2007Review
- Exact steady-state velocity of ratchets driven by random sequential adsorption.Journal of physics A: Mathematical and general · 2007Article
- Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity.Biopolymers · 2007Review
- Dynamics of DNA ejection from bacteriophage.Biophysical journal · 2006Article
- Computer simulation of polypeptide translocation through a nanopore.Journal of molecular modeling · 2005Article
- Measurements of DNA lengths remaining in a viral capsid after osmotically suppressed partial ejection.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the dynamics of the passage of a stiff chain through a pore into a cell containing particles that bind reversibly to it. Using Brownian molecular dynamics simulations we investigate the mean first-passage time as a function of the length of the chain inside for different concentrations of binding particles. As a consequence of the interactions with these particles, the chain experiences a net force along its length whose calculated value from the simulations accounts for the velocity at which it enters the cell. This force can in turn be obtained from the solution of a generalized diffusion equation incorporating an effective Langmuir adsorption free energy for the chain plus binding particles. These results suggest a role of binding particles in the translocation process that is in general quite different from that of a Brownian ratchet. Furthermore, nonequilibrium effects contribute significantly to the dynamics; e.g., the chain often enters the cell faster than particle binding can be saturated, resulting in a force several times smaller than the equilibrium value.
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