Trial reportBMC neurology2003
The Ischemic Stroke Genetics Study (ISGS) Protocol.
Trial report in BMC neurology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.Stroke · 2015Pooled it
- Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.Lancet (London, England) · 2011Pooled it
- Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis.PloS one · 2011Pooled it
- Trial
- Gene Expression Profiles at Early vs Late Stages After Cervical Artery Dissection.Neurology. Genetics · 2026Article
- Mechanisms of Preconditioning Exercise-Induced Neurovascular Protection in Stroke.Journal of stroke · 2021Review
- Using family members to augment genetic case-control studies of a life-threatening disease.Statistics in medicine · 2016Article
- Validation of the 8-item questionnaire for verifying stroke free status with and without pictograms in three West African languages.eNeurologicalSci · 2016Article
- Multilingual Validation of the Questionnaire for Verifying Stroke-Free Status in West Africa.Stroke · 2016Article
- TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease.Molecular neurodegeneration · 2013Article
- NINDS stroke genetics network (SiGN) experience with the causative classification system.International journal of stroke : official journal of the International Stroke Society · 2013Article
- Article
- Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.European journal of neurology · 2013Article
- Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population.Acta pharmacologica Sinica · 2011Article
- Bio-Repository of DNA in stroke (BRAINS): a study protocol.BMC medical genetics · 2011Article
- Common mitochondrial sequence variants in ischemic stroke.Annals of neurology · 2011Article
- Article
- Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.American journal of human genetics · 2010Article
- Candidate gene polymorphisms for ischemic stroke.Stroke · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThe molecular basis for the genetic risk of ischemic stroke is likely to be multigenic and influenced by environmental factors. Several small case-control studies have suggested associations between ischemic stroke and polymorphisms of genes that code for coagulation cascade proteins and platelet receptors. Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype. METHODS/
designThe Ischemic Stroke Genetic Study is a prospective, multicenter genetic association study in adults with recent first-ever ischemic stroke confirmed with computed tomography or magnetic resonance imaging. Patients are evaluated at academic medical centers in the United States and compared with sex- and age-matched controls. Stroke subtypes are determined by central blinded adjudication using standardized, validated mechanistic and syndromic classification systems. The panel of genes to be tested for polymorphisms includes beta-fibrinogen and platelet glycoprotein Ia, Iba, and IIb/IIIa. Immortalized cell lines are created to allow for time- and cost-efficient testing of additional candidate genes in the future. DISCUSSION: The study is designed to minimize survival bias and to allow for exploring associations between specific polymorphisms and individual subtypes of ischemic stroke. The data set will also permit the study of genetic determinants of stroke outcome. Having cell lines will permit testing of future candidate risk factor genes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.