ArticleThe Biochemical journal2003
Selective modulation of the SM22alpha promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Review
- Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells.Oncology letters · 2017Article
- A C2H2 zinc finger protein FEMU2 is required for fox1 expression in Chlamydomonas reinhardtii.PloS one · 2014Article
- Overexpression of KLF13 and FGFR3 in oral cancer cells.Cytogenetic and genome research · 2010Article
- Kruppel-like factor 4: transcriptional regulator of proliferation, or inflammation, or differentiation, or all three?Circulation research · 2008Article
- Kruppel-like Factors (KLFs) in muscle biology.Journal of molecular and cellular cardiology · 2007Review
- The Kruppel-like transcription factor KLF13 is a novel regulator of heart development.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously identified a C2H2 zinc-finger transcription factor [BTEB3 (basal transcription element-binding protein 3)/KLF13 (Krüppel-like factor 13)] that activates the minimal promoter for the smooth muscle-specific SM22alpha gene in other types of cell. We show that recombinant BTEB3 binds to three TGGG motifs in the minimal SM22alpha promoter. By mutation analysis, only one of these boxes is required for BTEB3-dependent promoter activation in P19 cells and BTEB3 activates or inhibits reporter gene expression depending on the TGGG box to which it binds. Transient transfection experiments show that BTEB3 also activates reporter gene expression from the SM22alpha promoter in VSMCs (vascular smooth muscle cells). Similar studies showed that BTEB3 did not activate expression from the promoter regions of the smooth muscle myosin heavy chain or smooth muscle alpha-actin promoters, which contain similar sequences, implying that promoter activation by BTEB3 is selective. The expression of BTEB3 is readily detectable in VSMCs in vitro and is modulated in response to injury in vivo.
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