ReviewJournal of bioenergetics and biomembranes2003
New insights into Nm23 control of cell adhesion and migration.
Review in Journal of bioenergetics and biomembranes, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction.Cardiovascular diabetology · 2025Article
- Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes.International journal of molecular sciences · 2024Article
- Mitochondrial NME6 Influences Basic Cellular Processes in Tumor Cells In Vitro.International journal of molecular sciences · 2024Article
- Mechanisms of action of NME metastasis suppressors - a family affair.Cancer metastasis reviews · 2023Review
- Characterization of a group I Nme protein of Capsaspora owczarzaki-a close unicellular relative of animals.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Rho GAPs and GEFs: controling switches in endothelial cell adhesion.Cell adhesion & migration · 2014Review
- NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans.PloS one · 2014Article
- Innovative therapeutic strategies in the treatment of brain metastases.International journal of molecular sciences · 2013Article
- Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.Nucleic acids research · 2012Article
- A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway.Journal of experimental & clinical cancer research : CR · 2011Article
- The anti-metastatic nm23-1 gene is needed for the final step of mammary duct maturation of the mouse nipple.PloS one · 2011Article
- Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans.BMC evolutionary biology · 2011Article
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- Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1.Journal of experimental & clinical cancer research : CR · 2010Article
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- Subcellular localization of Nm23/NDPK A and B isoforms: a reflection of their biological function?Molecular and cellular biochemistry · 2009Review
- The mammalian Nm23/NDPK family: from metastasis control to cilia movement.Molecular and cellular biochemistry · 2009Review
- Role of nm23 in the regulation of cell shape and migration via Rho family GTPase signals.Molecular and cellular biochemistry · 2009Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms underlying the role of Nm23/NDP kinase in controlling cell migration and metastasis have been investigated. The recent progress in our understanding of cell migration at a molecular level gives us some clues to the putative Nm23 function as a suppressor of metastasis. Screening of the literature indicates that NDP kinases have pleiotropic effects. By modifying cytoskeleton organization and protein trafficking, some NDP kinase isoforms may indirectly promote adhesion to the extracellular matrix in some cell types. Conversely, Nm23 regulates cell surface expression of integrin receptors and matrix metallo-proteases, and thus directly controls the cell adhesion machinery. Finally, the recent discovery of the interaction between Nm23-H2 and the negative regulator of beta1 integrin-mediated cell adhesion, ICAP-1, which targets the kinase to lamellipodia and cell protrusions, suggests that the Nm23-H2/ICAP-1 complex plays a role in integrin signaling, and exerts a fine-tuning between migration and spreading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.