ReviewLipids2003
The structure of DHA in phospholipid membranes.
Review in Lipids, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Comparing multislice projections of MD simulations with cryo-EM exposes structural prediction errors.Biophysical journal · 2026Article
- Comparing Multislice Projections of MD Simulations with CryoEM Exposes Structural Prediction Errors.bioRxiv : the preprint server for biology · 2026Article
- Physiological Effects of Water Salinity on Metabolism and Fatty Acid Biosynthesis in the Model FishAnimals : an open access journal from MDPI · 2025Article
- Article
- Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery.Communications materials · 2025Review
- Docosahexaenoic Acid Explains the Unexplained in Visual Transduction.Entropy (Basel, Switzerland) · 2023Article
- Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function.Cold Spring Harbor perspectives in biology · 2023Review
- Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.Molecular psychiatry · 2023Article
- Special issue for Klaus Gawrisch.Biophysical journal · 2023Article
- Brominated lipid probes expose structural asymmetries in constricted membranes.Nature structural & molecular biology · 2023Article
- Influence of very-long-chain polyunsaturated fatty acids on membrane structure and dynamics.Biophysical journal · 2022Article
- Order vs. Disorder: Cholesterol and Omega-3 Phospholipids Determine Biomembrane Organization.International journal of molecular sciences · 2022Article
- Article
- Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle.Nutrients · 2021Review
- Distinct Influence of Omega-3 Fatty Acids on the Plasma Metabolome of Healthy Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- The combined impacts of docosahexaenoic acid, endurance physical exercise, and prolonged fasting on brain function.Journal of exercise rehabilitation · 2018Review
- Elucidating the structural organization of a novel low-density lipoprotein nanoparticle reconstituted with docosahexaenoic acid.Chemistry and physics of lipids · 2017Article
- Review
- Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression.The Journal of biological chemistry · 2016Article
- Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c.Biophysical journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Early experiments and molecular simulations of PUFA favored a rigid arrangement of double bonds in U-shaped or extended conformations such as angle-iron or helical. Although results of recent solid-state NMR measurements and molecular simulations have confirmed the existence of these structural motifs, they portray an image of DHA (22:6n-3) as a highly flexible molecule with rapid transitions between large numbers of conformers on the time scale from picoseconds to hundreds of nanoseconds. The low barriers to torsional rotation about C-C bonds that link the cis-locked double bonds with the methylene carbons between them are responsible for this unusual flexibility. Both the amplitude and frequency of motion increase toward the terminal methyl group of DHA.
Indexed as
Identifiers
12848292What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.