ArticleGenes and immunity2003
The SDF1-G801A polymorphism is not associated with SDF1 gene expression in Epstein-Barr virus-transformed lymphoblastoid cells.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of SDF-1 and CXCR4 gene variants on the development of diabetic kidney disease.International journal of medical sciences · 2024Article
- Significance of CXCL12 in type 2 diabetes mellitus and its associated complications.Inflammation · 2015Review
- CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer.Clinical and experimental medicine · 2013Article
- The SDF-1α3'A genetic variation is correlated with susceptibility of asthma in Iranian patients.BioMed research international · 2013Article
- Article
- SDF1-3' a gene polymorphism is associated with laryngeal cancer.Pathology oncology research : POR · 2010Article
- Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population.Molecular biology reports · 2010Article
- The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation.Bone marrow transplantation · 2009Article
- SDF-1 and CCR5 genes polymorphism in patients with head and neck cancer.Pathology oncology research : POR · 2008Article
- Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells.Oncogene · 2008Article
- The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.Clinical and experimental immunology · 2007Review
- Review
- Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis.Oncogene · 2006Article
- Cis-acting effect of the IL1B C-31T polymorphism on IL-1 beta mRNA expression.Genes and immunity · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of the SDF1-3'A on AIDS progression have been attributed to the altered amount of stromal cell-derived factor 1 (SDF-1). However, the contribution of the SDF1-G801A polymorphism to SDF-1 expression is still unclear. In contrast to fresh peripheral blood mononuclear cells (PBMCs), Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) express the SDF-1 mRNA. Using EBV-transformed LCLs from 42 individuals with different genotypes, we investigated the SDF-1 mRNA levels and methylation status in the SDF1 gene. Both in PBMCs and in EBV-transformed LCLs, CpG dinucleotides in the 5' region of the SDF1 gene were unmethylated. As for the 3' untranslated region (3'UTR), by contrast, CpG dinucleotides were methylated in PBMCs, whereas site-specific demethylation around the polymorphic site was detected in EBV-transformed LCLs. The levels of the demethylation were correlated with the SDF-1 mRNA levels. However, the genotype for the SDF1-G801A polymorphism did not significantly alter the SDF-1 mRNA levels. The allele preferences in transcription and methylation were also absent in the heterozygous cells. In conclusion, this study suggested a contribution of site-specific demethylation in the 3'UTR to the SDF1 gene expression, but did not show any evidence for the contribution of the SDF1-G801A polymorphism to the amount of the SDF-1 mRNA.
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