ArticleThe Journal of experimental medicine2003
Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 164 citations in OpenAlex.
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- Lung-resident CD69The Journal of allergy and clinical immunology · 2023Article
- Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1.Nature microbiology · 2019Article
- Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.Mucosal immunology · 2016Article
- Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.Journal of virology · 2014Article
- Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.PloS one · 2014Article
- PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection.Journal of virology · 2013Article
- Pulmonary dendritic cell development and antigen acquisition.Immunologic research · 2013Review
- Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of γδ T cells.Journal of virology · 2012Article
- Harnessing human plasmacytoid dendritic cells as professional APCs.Cancer immunology, immunotherapy : CII · 2012Review
- Epithelial cells, the "switchboard" of respiratory immune defense responses: effects of air pollutants.Swiss medical weekly · 2012Review
- Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.PloS one · 2012Article
- Granulocyte colony-stimulating factor protects mice during respiratory virus infections.PloS one · 2012Article
- Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection.PLoS pathogens · 2011Article
- Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens.Infection and immunity · 2011Article
- Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation.The Journal of experimental medicine · 2011Article
- Dendritic cell subsets as vectors and targets for improved cancer therapy.Current topics in microbiology and immunology · 2011Review
- Dendritic cells and immunity against cancer.Journal of internal medicine · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We evaluated the proposal that during microbial infection, dendritic cells (DCs) undergo maturation and present a mixture of peptides derived from the microbe as well as harmless environmental antigens. Mice were exposed to an aerosol of endotoxin free ovalbumin (OVA) in the absence or presence of influenza virus. In its absence, OVA failed to induce B and T cell responses and even tolerized, but with influenza, OVA-specific antibodies and CD8+ cytolytic T lymphocytes developed. With or without infection, OVA was presented selectively in the draining mediastinal lymph nodes, as assessed by the comparable proliferation of infused, CD8+ and CD4+, TCR transgenic T cells. In the absence of influenza, these OVA-specific T cells produced little IL-2, IL-4, IL-10, and IFN-gamma, but with infection, both CD4+ and CD8+ T cells made high levels of IL-2 and IFN-gamma. The OVA plus influenza-treated mice also showed accelerated recovery to a challenge with recombinant vaccinia OVA virus. CD11c+ DCs from the mediastinal lymph nodes of infected mice selectively stimulated both OVA- and influenza-specific T cells and underwent maturation, with higher levels of MHC class II, CD80, and CD86 molecules. The relatively slow (2-3 d) kinetics of maturation correlated closely to the time at which OVA inhalation elicited specific antibodies. Therefore respiratory infection can induce DC maturation and simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.