ArticleThe Journal of cell biology2003
Lack of GTP-bound Rho1p in secretory vesicles of Saccharomyces cerevisiae.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal PathogenACS infectious diseases · 2020Article
- Mechanical feedback coordinates cell wall expansion and assembly in yeast mating morphogenesis.PLoS computational biology · 2018Article
- A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast.Molecular biology of the cell · 2017Article
- Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.The Journal of biological chemistry · 2017Article
- Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit.PLoS genetics · 2016Article
- Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase.The Journal of cell biology · 2016Article
- Plant-derived antifungal agent poacic acid targets β-1,3-glucan.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues.PloS one · 2015Article
- TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.Molecular biology of the cell · 2014Article
- Compact modeling of allosteric multisite proteins: application to a cell size checkpoint.PLoS computational biology · 2014Article
- Proteins involved in building, maintaining and remodeling of yeast cell walls.Current genetics · 2013Article
- The spatial distribution of the exocyst and actin cortical patches is sufficient to organize hyphal tip growth.Eukaryotic cell · 2013Article
- Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.Current opinion in cell biology · 2012Review
- Cell polarization and cytokinesis in budding yeast.Genetics · 2012Review
- A link between mitotic entry and membrane growth suggests a novel model for cell size control.The Journal of cell biology · 2012Article
- Morphogenesis and the cell cycle.Genetics · 2012Review
- Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.Genetics · 2011Review
- Quantitative proteomics of yeast post-Golgi vesicles reveals a discriminating role for Sro7p in protein secretion.Traffic (Copenhagen, Denmark) · 2011Article
- Requirements of Slm proteins for proper eisosome organization, endocytic trafficking and recycling in the yeast Saccharomyces cerevisiae.Journal of biosciences · 2011Article
- A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.Molecular genetics and genomics : MGG · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rho1p, an essential Rho-type GTPase in Saccharomyces cerevisiae, activates its effectors in the GTP-bound form. Here, we show that Rho1p in secretory vesicles cannot activate 1,3-beta-glucan synthase, a cell wall synthesizing enzyme, during vesicular transport to the plasma membrane. Analyses with an antibody preferentially reacting with the GTP-bound form of Rho1p revealed that Rho1p remains in the inactive form in secretory vesicles. Rom2p, the GDP/GTP exchange factor of Rho1p, is preferentially localized on the plasma membrane even when vesicular transport is blocked. Overexpression of Rom2p results in delocalization of Rom2p and accumulation of 1,3-beta-glucan in secretory vesicles. Based on these results, we propose that Rho1p is kept inactive in intracellular secretory organelles, resulting in repression of the activity of the cell wall-synthesizing enzyme within cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.