ArticleNeurosurgical review2003
Proliferation, migration, and invasion of human glioma cells exposed to fractionated radiotherapy in vitro.
Article in Neurosurgical review, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Review
- Towards a comprehensive approach for characterizing cell activity in bright-field microscopic images.Scientific reports · 2022Article
- A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment.NPJ precision oncology · 2022Article
- Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives.Cancers · 2022Review
- Inhibition of glioblastoma growth and invasion byAmerican journal of translational research · 2017Article
- Phenotypic Transition as a Survival Strategy of Glioma.Neurologia medico-chirurgica · 2016Review
- Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model.PloS one · 2016Article
- Wnt/β-catenin pathway involvement in ionizing radiation-induced invasion of U87 glioblastoma cells.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015Article
- Identifying new small molecule anti-invasive compounds for glioma treatment.Cell cycle (Georgetown, Tex.) · 2013Review
- Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition.Cancer gene therapy · 2011Article
- Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery.Journal of neuro-oncology · 2007Article
- Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration.Journal of cancer research and clinical oncology · 2005Article
- Radiation sterilisation of cultured human brain tumour cells for clinical immune tumour therapy.British journal of cancer · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is a well established treatment for malignant gliomas. This study describes the migration, proliferation, and invasion behaviour of two human glioma cell lines (GaMg and U-87 Mg) grown as multicellular tumour spheroids after radiotherapy. Migration and proliferation studies were performed using conventional and accelerated fractionation up to 60 Gy and 59.4 Gy, respectively. A dose-dependent growth and migratory response to irradiation independent of the type of fractionation was observed. A coculture system in which tumour spheroids were confronted with foetal rat brain aggregates was used for invasion studies. Marked invasion of the glioma spheroids into the brain aggregates occurred with or without radiotherapy. For the GaMg cells, flow cytometric DNA histograms after treatment with 10 Gy and 40 Gy showed an accumulation of cells in the G2/M phase of the cell cycle. Radiotherapy inhibits tumour cell growth and migration, but the invasiveness of the remaining tumour cells seems to be unaffected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.