ArticleImmunogenetics2003
IGH V3-23*01 and its allele V3-23*03 differ in their capacity to form the canonical human antibody combining site specific for the capsular polysaccharide of Haemophilus influenzae type b.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry.Genes and immunity · 2024Article
- Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.NPJ vaccines · 2024Article
- Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African Swine Fever Virus.Vaccines · 2023Article
- Access to ultra-long IgG CDRH3 bovine antibody sequences using short read sequencing technology.Molecular immunology · 2021Article
- Article
- Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations.Genes and immunity · 2021Article
- Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire.Frontiers in immunology · 2021Review
- Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data.PLoS computational biology · 2019Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.Nature communications · 2017Article
- The Individual and Population Genetics of Antibody Immunity.Trends in immunology · 2017Review
- Estimating Copy Number and Allelic Variation at the Immunoglobulin Heavy Chain Locus Using Short Reads.PLoS computational biology · 2016Article
- The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein.mBio · 2015Article
- Identification of antigen-specific B cell receptor sequences using public repertoire analysis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor Repertoire.Frontiers in immunology · 2015Article
- The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.Genes and immunity · 2012Review
- The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
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2 authors.
Funding
Abstract
The IGH V3-23*01 gene is used in the formation of the canonical combining site which dominates the human antibody repertoire to the Haemophilus influenzae type b (Hib) polysaccharide (PS). An allele of the human IGH V3-23*01 gene, known as V3-23*03, differs from V3-23*01 in nine bases, eight of which are located in the second complementarity determining region. These eight differences encode five amino acid substitutions. In this study we investigated whether the V3-23*03 sequence polymorphism affected Hib PS binding. We constructed two Fab fragments that had the canonical Hib PS combining site VH-VL configuration but that had either V3-23*01 or V3-23*03. Radioantigen binding assay showed that on a concentration basis the V3-23*03 Fab was 20-fold more effective in binding Hib PS than the V3-23*01 Fab. The V3-23*03 Fab was 4-fold more effective than the V3-23*01 Fab in mediating facilitated bactericidal activity against Hib organisms. These findings identify a functional consequence of V3-23 allelism, and suggest that utilization of the V3-23*03 gene in the human Hib PS repertoire would generate canonical antibodies with higher affinity and protective efficacy than canonical antibodies utilizing V3-23*01. Thus, IGH V gene allelic variation has the potential to impact the generation of protective immunity to Hib.
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