Evidence map›Paper›PMID 12845459›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2003

Agenesis of corpus callosum: prenatal diagnosis and prognosis.

Marie-Laure Moutard, Virginie Kieffer, Josué Feingold, François Kieffer, Fanny Lewin, Catherine Adamsbaum, Antoinette Gélot, Jaume Campistol I Plana, Patrick van Bogaert, Monique André and 1 more

Registry-linked trialAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02267161 (Outcome of Infants With Prenatal Corpus Callosum Agenesis), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02267161 nacompletednot on this mapstarted 2015, after this paper: background citation

Outcome of Infants With Prenatal Corpus Callosum Agenesis

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2015 to 2022Enrolled72ConditionsAgenesis of the Corpus CallosumArmsPsychometric scales for infants at 3 years of age
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 158 citations in OpenAlex.

  1. Article
  2. Prenatal evaluation, diagnosis and management of fetal corpus callosal abnormalities: international Delphi consensus.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  3. Visualization of the Fetal Corpus Callosum in Routine Second Trimester Screening Ultrasound Examinations.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  4. Article
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  13. Review
  14. Article
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  16. Article
  17. Callosal dysgenesis in fetuses with ventriculomegaly: levels of agreement between imaging modalities and postnatal outcome.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2012
    Article
  18. Fetal hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011
    Article
  19. Article
  20. Corpus callosum agenesis and rehabilitative treatment.Italian journal of pediatrics · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Marie-Laure MoutardServices de Neuropédiatrie, Obstétrique, Radiologie, Hôpital Saint Vincent de Paul, 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France. marielaure.moutard@svp.ap-hop-paris.fr
Virginie Kieffer
Josué Feingold
François Kieffer
Fanny Lewin
Catherine Adamsbaum
Antoinette Gélot
Jaume Campistol I Plana
Patrick van Bogaert
Monique André
Gérard Ponsot
Hôpital Saint-Vincent-de-Paul · FRErasmus Hospital · BEHôpital Armand-Trousseau · FRHospital Sant Joan de Déu Barcelona · ESInstitut de Soudure · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAgenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.

methodsNeuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.

resultsFebrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80-109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80-89) increased and slowness, attentional troubles, and instability appeared.

conclusionThis study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.

Indexed as

Agenesis of Corpus CallosumPrenatal DiagnosisAge FactorsAnalysis of VarianceAttentionChildChild, PreschoolCorpus CallosumDental Enamel HypoplasiaElectroencephalographyEpilepsyFemaleFollow-Up StudiesHumansIntelligenceIntelligence Tests

Identifiers

PMID12845459
OpenAlexW1966254971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.