ArticleIntensive care medicine2003
Effect of cardiopulmonary bypass on lactate metabolism.
Article in Intensive care medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 185 citations in OpenAlex.
- Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety.Critical care (London, England) · 2014Trial
- Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.Intensive care medicine · 2009Trial
- Half-molar sodium-lactate solution has a beneficial effect in patients after coronary artery bypass grafting.Intensive care medicine · 2008Trial
- Development and Validation of an Interpretable Model for Predicting Postoperative Hyperlactatemia in Young Children Following Congenital Heart Surgery.Journal of clinical medicine · 2026Article
- The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation.Biomarkers in medicine · 2025Article
- Article
- Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights.Journal of personalized medicine · 2023Review
- Does severe hyperlactatemia during cardiopulmonary bypass predict a worse outcome?Annals of medicine and surgery (2012) · 2022Article
- Development and validation of a nomogram model for early postoperative hyperlactatemia in patients undergoing cardiac surgery.Journal of thoracic disease · 2021Article
- ΔPCOFrontiers in cardiovascular medicine · 2021Article
- Nomogram Models to Predict Postoperative Hyperlactatemia in Patients Undergoing Elective Cardiac Surgery.Frontiers in medicine · 2021Article
- Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery.PloS one · 2018Article
- Veno-arterial extracorporeal membrane oxygenation (VA ECMO) in postcardiotomy cardiogenic shock: how much pump flow is enough?Journal of thoracic disease · 2016Article
- Outcomes of post-cardiac surgery patients with persistent hyperlactatemia in the intensive care unit: a matched cohort study.Journal of cardiothoracic surgery · 2016Article
- Serum Lactate Is not Correlated with Mixed or Central Venous Oxygen Saturation for Detecting Tissue Hypo Perfusion During Coronary Artery Bypass Graft Surgery: A Prospective Observational Study.International cardiovascular research journal · 2013Article
- Effect of hyperosmolar sodium lactate infusion on haemodynamic status and fluid balance compared with hydroxyethyl starch 6% during the cardiac surgery.Indian journal of anaesthesia · 2013Article
- Clinical use of lactate monitoring in critically ill patients.Annals of intensive care · 2013Article
- Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006.Intensive care medicine · 2007Article
- Cardiac biochemical monitoring for the detection of acute myocardial ischemia.Intensive care medicine · 2006Article
- Year in review in intensive care medicine: 2003. II. Brain injury, hemodynamics, gastrointestinal tract, renal failure, metabolism, trauma, and postoperative.Intensive care medicine · 2004Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe have investigated the role of cardiopulmonary bypass on lactate metabolism in patients undergoing uncomplicated surgery for elective coronary artery bypass grafting (CABG).
designProspective non-randomized observational study. SETTINGS: National Cardiovascular Center. PATIENTS. Three independent groups were studied: preoperative ( n=20), postoperative with bypass (CPB, n=20) and postoperative without bypass (NO-CPB, n=20).
interventionsLactate metabolism was investigated with the use of an exogenous lactate challenge test (2.5 mmol Na-lactate/kg body weight in 15 min). Blood lactate was sequentially determined after the end of infusion. Lactate clearance and endogenous production were estimated from the area under the curve, and a bi-exponential fitting permitted modeling the lactate-decay into two compartments. MEASUREMENTS AND MAIN
resultsLactate metabolism parameters (basal lactate, clearance, endogenous production and half-lives [HL] I and II) were not different between the NO-CPB and preoperative groups. In the CPB group, as compared to the other two groups, basal lactate and endogenous production were not significantly affected while lactate clearance (CPB: 6.02+/-0.97 versus preoperative: 9.41+/-0.93 and NO-CPB: 9.6+/-0.8 ml/kg per min) and HL-I (CPB: 10.6+/-1.4 versus preoperative: 17.2+/-2.3 and NO-CPB: 18.8+/-2.5 min) were decreased ( p<0.001) and HL-II was increased (CPB: 171+/-41 versus preoperative: 73+/-12 and NO-CPB: 48+/-2.9 min, p<0.01).
conclusionWhile surgery and anesthesia per se do not seem to alter lactate metabolism, CPB significantly decreased lactate clearance, this effect being possibly related to a mild liver dysfunction even in uncomplicated elective surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.