ArticleTransgenic research1992
Expression of the whey acidic protein in transgenic pigs impairs mammary development.
Article in Transgenic research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
- The tammar wallaby: A marsupial model to examine the timed delivery and role of bioactives in milk.General and comparative endocrinology · 2017Review
- Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.Genesis (New York, N.Y. : 2000) · 2009Article
- High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits.Transgenic research · 2006Article
- Mfge8 is critical for mammary gland remodeling during involution.Molecular biology of the cell · 2005Article
- Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.Development (Cambridge, England) · 2004Article
- The comparative biology of whey proteins.Journal of mammary gland biology and neoplasia · 2002Review
- Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels.Transgenic research · 2001Article
- Transgenic animal bioreactors.Transgenic research · 2000Review
- Modification and repression of genes expressed in the mammary gland using gene targeting and other technologies.Journal of mammary gland biology and neoplasia · 1998Review
- C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.Genes & development · 1998Article
- Synthesis and secretion of the mouse whey acidic protein in transgenic sheep.Transgenic research · 1996Article
- Regulation of human protein C gene expression by the mouse WAP promoter.Transgenic research · 1994Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The whey acidic protein has been found in milk of mice, rats, rabbits and camels, and its gene is expressed specifically in mammary tissue at late pregnancy and throughout lactation. A characteristic of whey acidic protein is the 'four-disulfide-core' signature which is also present in proteins involved in organ development. We have generated six lines of transgenic pigs which carry a mouse whey acidic protein transgene and express it at high levels in their mammary glands. Transgenic sows from three lines could not produce sufficient quantities of milk to support normal development of healthy offspring. This phenotype appears to be similar, if not identical, to the milchlos phenotype exhibited by mice expressing whey acidic protein transgenes. Mammary tissue from post-partum milchlos sows had an immature histological appearance, which was distinct from that observed during normal development or involution. Expression of the whey acidic protein transgene was found in mammary tissue from sexually immature pigs from milchlos lines, but not in sows from lines that appeared to lactate normally. We suggest that precocious synthesis of whey acidic protein impairs mammary development and function. Impaired mammary development due to inappropriate timing of whey acidic protein expression is consistent with the notion that proteins with the 'four-disulfide-core' signature participate in tissue formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.