ArticleAmerican journal of human genetics2003
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Diverse mutational mechanisms cause pathogenic subtelomeric rearrangements.Human molecular genetics · 2011Article
- Analysis of human meiotic recombination events with a parent-sibling tracing approach.BMC genomics · 2011Article
- Widespread RNA and DNA sequence differences in the human transcriptome.Science (New York, N.Y.) · 2011Article
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- Meiotic recombination in human oocytes.PLoS genetics · 2009Article
- SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data.BMC bioinformatics · 2009Article
- Cytological studies of recombination in rhesus males.Cytogenetic and genome research · 2009Article
- Genomic determinants of the efficiency of internal ribosomal entry sites of viral and cellular origin.Nucleic acids research · 2008Article
- Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.American journal of human genetics · 2008Article
- In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.PLoS biology · 2008Article
- Human subtelomeric WASH genes encode a new subclass of the WASP family.PLoS genetics · 2007Article
- Family-based association tests for genomewide association scans.American journal of human genetics · 2007Article
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- Distributions of single nucleotide polymorphisms in differential chromosome segments of congenic resistant strains that define minor histocompatibility antigens.Immunogenetics · 2007Article
- Polymorphic variation in human meiotic recombination.American journal of human genetics · 2007Article
- Elevated rates of sister chromatid exchange at chromosome ends.PLoS genetics · 2007Article
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in technologies for high-throughout single-nucleotide polymorphism (SNP)-based genotyping have improved efficiency and cost so that it is now becoming reasonable to consider the use of SNPs for genomewide linkage analysis. However, a suitable screening set of SNPs and a corresponding linkage map have yet to be described. The SNP maps described here fill this void and provide a resource for fast genome scanning for disease genes. We have evaluated 6,297 SNPs in a diversity panel composed of European Americans, African Americans, and Asians. The markers were assessed for assay robustness, suitable allele frequencies, and informativeness of multi-SNP clusters. Individuals from 56 Centre d'Etude du Polymorphisme Humain pedigrees, with >770 potentially informative meioses altogether, were genotyped with a subset of 2,988 SNPs, for map construction. Extensive genotyping-error analysis was performed, and the resulting SNP linkage map has an average map resolution of 3.9 cM, with map positions containing either a single SNP or several tightly linked SNPs. The order of markers on this map compares favorably with several other linkage and physical maps. We compared map distances between the SNP linkage map and the interpolated SNP linkage map constructed by the deCode Genetics group. We also evaluated cM/Mb distance ratios in females and males, along each chromosome, showing broadly defined regions of increased and decreased rates of recombination. Evaluations indicate that this SNP screening set is more informative than the Marshfield Clinic's commonly used microsatellite-based screening set.
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