ArticleHistochemistry and cell biology2003
Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Tritrichomonas foetus.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Detection of Pseudocyst Forms ofIranian journal of public health · 2018Article
- Evaluation of the effect of miltefosine on Trichomonas vaginalis.Parasitology research · 2014Article
- Naturally occurring triggers that induce apoptosis-like programmed cell death in Plasmodium berghei ookinetes.PloS one · 2010Article
- Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.BMC microbiology · 2009Article
- SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model.Journal of bacteriology · 2007Article
- Cell death in trichomonads: new insights.Histochemistry and cell biology · 2006Article
- Tritrichomonas foetus pseudocysts adhere to vaginal epithelial cells in a contact-dependent manner.Parasitology research · 2004Article
- The effect of drugs on cell structure of Tritrichomonas foetus.Parasitology research · 2004Article
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
- Peroxisome proliferation in Foraminifera inhabiting the chemocline: an adaptation to reactive oxygen species exposure?The Journal of eukaryotic microbiologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tritrichomonas foetus is an amitochondrial parasite protist which lacks typical eukaryote organelles such as mitochondria and peroxisomes, but possesses the hydrogenosome, a double-membrane-bound organelle that produces ATP. The cell death of amitochondrial organisms is poorly studied. In the present work, the cytotoxic effects of hydrogen peroxide on T. foetus and its participation on cell death were analyzed. We took advantage of several microscopy techniques, including videomicroscopy, light microscopy immunocytochemistry for detection of caspase activation, and scanning and transmission electron microscopy. We report here that in T. foetus: (1) H(2)O(2) leads to loss of motility and induces cell death, (2) the dying cells exhibit some characteristics similar to those found during the death of other organisms, and (3) a caspase-like protein seems to be activated during the death process. Thus, we propose that, although T. foetus does not present mitochondria nor any known pathways of cell death, it is likely that it bears mechanisms of cell demise. T. foetus exhibits morphological and physiological alterations in response to H(2)O(2) treatment. The hydrogenosome, a unique organelle which is supposed to share a common ancestral origin with mitochondria and has an important role in oxidative responses in trichomonads, is a candidate for participating in this event.
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