ArticleJournal of computational neuroscience
Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT.
Article in Journal of computational neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- NEURONpyxl: fast, flexible, Python-integrated simulation of biophysical neural networks with complex plastic synapses.Frontiers in computational neuroscience · 2026Article
- Role of A-type K+ channels in spike broadening observed in soma and axon of Hermissenda type-B photoreceptors: a simulation study.Journal of computational neuroscience · 2006Article
- Subcellular, cellular, and circuit mechanisms underlying classical conditioning in Hermissenda crassicornis.Anatomical record. Part B, New anatomist · 2006Review
- Octopamine increases the excitability of neurons in the snail feeding system by modulation of inward sodium current but not outward potassium currents.BMC neuroscience · 2005Article
- Inhibition of conditioned stimulus pathway phosphoprotein 24 expression blocks the reduction in A-type transient K+ current produced by one-trial in vitro conditioning of Hermissenda.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda.Journal of computational neuroscienceArticle
- A computational study of the role of spike broadening in synaptic facilitation of Hermissenda.Journal of computational neuroscienceArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K+ current (I(K,A)), sustained Ca2+ current (I(Ca,S)), Ca-dependent K+ current (I(K,Ca)), and a hyperpolarization-activated inward rectifier current (I(h)). In this study, we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. Ion currents were systematically varied within limits observed experimentally, both individually and in combinations. A reduction of I(K,A) or I(K,Ca), or an increase in I(h) enhanced excitability by 20-50%. Decreasing I(Ca,S) produced a dramatic decrease in excitability. Reductions of I(K,V) produced only minimal increases in excitability, suggesting that I(K,V) probably plays a minor role in 5-HT induced enhanced excitability. Combinations of changes in I(K,A), I(K,Ca), I(h) and I(Ca,S) produced increases in excitability comparable to experimental observations. After 5-HT application, the cell's depolarization force is shifted from the I(h)-I(Ca,S) combination to predominantly I(h).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.