ArticleJournal of computational neuroscience
A computational study of the role of spike broadening in synaptic facilitation of Hermissenda.
Article in Journal of computational neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Role of A-type K+ channels in spike broadening observed in soma and axon of Hermissenda type-B photoreceptors: a simulation study.Journal of computational neuroscience · 2006Article
- Subcellular, cellular, and circuit mechanisms underlying classical conditioning in Hermissenda crassicornis.Anatomical record. Part B, New anatomist · 2006Review
- Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda.Journal of computational neuroscienceArticle
- Extending in vitro conditioning in Aplysia to analyze operant and classical processes in the same preparation.Learning & memory (Cold Spring Harbor, N.Y.)Article
- Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT.Journal of computational neuroscienceArticle
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Authors and funding
4 authors.
Funding
Abstract
Pavlovian conditioning in Hermissenda produces a decrease in voltage-dependent (I(K,A) and I(Ca)) and Ca2+-dependent (I(K,Ca)) currents, and an increase in the action potential (AP) duration in type B-photoreceptors. In addition, synaptic connections between B and A photoreceptors and B photoreceptor and type I interneurons are facilitated. The increase in AP duration, produced by decreasing one or more K+ currents, may account for synaptic facilitation. The present study examined this issue by using a mathematical model of the B-photoreceptor and the neurosimulator SNNAP. In the model, decreasing g(K,A) by 70% increased the duration of the AP in the terminal by 41% and Ca2+ influx by 30%. However, if the decrease in g(K,A) was combined with a decrease in g(Ca), similar to what has been reported experimentally, the Ca2+ influx decreased by 54%. Therefore, the concomitant change in I(Ca) counter-acted the broadening-induced increase in Ca2+ influx in the synaptic terminal. This result suggests that a spike-duration independent process must contribute to the synaptic facilitation observed following Pavlovian conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.