ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Characterization of depolarization-induced suppression of inhibition using paired interneuron--Purkinje cell recordings.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 73 citations in OpenAlex.
- Principles of visual cortex excitatory microcircuit organization.Innovation (Cambridge (Mass.)) · 2025Article
- Presynaptic Adrenoceptors.Handbook of experimental pharmacology · 2024Review
- Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.Frontiers in cellular neuroscience · 2022Article
- Cannabinoid type 2 receptors inhibit GABAA receptor-mediated currents in cerebellar Purkinje cells of juvenile mice.PloS one · 2020Article
- Modulation of Ion Channels in the Axon: Mechanisms and Function.Frontiers in cellular neuroscience · 2019Review
- Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cannabinoid modulation of memory consolidation within the cerebellum.Neurobiology of learning and memory · 2016Article
- GABABR-Dependent Long-Term Depression at Hippocampal Synapses between CB1-Positive Interneurons and CA1 Pyramidal Cells.Frontiers in cellular neuroscience · 2016Article
- Cerebellar endocannabinoids: retrograde signaling from purkinje cells.Cerebellum (London, England) · 2015Review
- Optogenetic identification of an intrinsic cholinergically driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1.The Journal of physiology · 2014Article
- Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex.Frontiers in synaptic neuroscience · 2014Review
- Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reliable evaluation of the quantal determinants of synaptic efficacy using Bayesian analysis.Journal of neurophysiology · 2013Article
- Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus.Purinergic signalling · 2012Article
- Distributed synergistic plasticity and cerebellar learning.Nature reviews. Neuroscience · 2012Review
- Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.Frontiers in cellular neuroscience · 2012Article
- Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex.British journal of pharmacology · 2011Article
- Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.Nature neuroscience · 2011Article
- Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depolarization-induced suppression of inhibition (DSI) is a retrograde form of synaptic inhibition involving the Ca2+-dependent release of cannabinoids from the postsynaptic cell. DSI exerts multiple effects on presynaptic neurons: here, we establish the breakdown of DSI in its individual components at the synapses between basket and stellate cells and Purkinje cells. In the presence of tetrodotoxin, the change in IPSC frequency entirely accounted for the decrease of transmission during DSI; in contrast, without tetrodotoxin, the reductions of frequency and average amplitude gave equal contributions. In paired recordings, transmission displayed an irreversible rundown unless interneurons were recorded from with the perforated patch method. Under these conditions, a DSI of 68.8% was measured; the failure rate and the paired pulse ratio (at 20 msec intervals) increased from 1.2 to 20.2 and 95.6 to 132.6%, respectively, and the variance to mean ratio augmented 2.17-fold. Presynaptic dialysis with Cs+ led to a major potentiation of synaptic strength and to a marked reduction of DSI with respect to control potassium conditions; DSI recovered only partially when decreasing the extracellular Ca2+ concentration to match the control IPSC amplitudes. These results, combined with those of Kreitzer et al. (2002), indicate that three distinct presynaptic processes contribute to DSI: reductions of miniature frequency (13.4% of total DSI), of presynaptic action potential frequency (23.2%), and of the probability that presynaptic depolarizations elicit transmitter release (63.4%). The latter component involves a modulation of K+ channels and trial-to-trial modifications of the presynaptic signal.
Indexed as
Identifiers
12843295PMC6741228W1532406678What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.