ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Beta-adrenergic antagonists during general anesthesia reduced postoperative pain: a systematic review and a meta-analysis of randomized controlled trials.Journal of anesthesia · 2015Pooled it
- Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines.Biophysical journal · 2019Article
- Norepinephrine Induces PTSD-Like Memory ImpairmentsFrontiers in behavioral neuroscience · 2019Article
- β-adrenergic signaling broadly contributes to LTP induction.PLoS computational biology · 2017Article
- β-Adrenergic Control of Hippocampal Function: Subserving the Choreography of Synaptic Information Storage and Memory.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.PLoS computational biology · 2016Article
- β-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Stress induces pain transition by potentiation of AMPA receptor phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.The Journal of biological chemistry · 2014Article
- The developmental stages of synaptic plasticity.The Journal of physiology · 2014Review
- Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices.Neuroscience bulletin · 2013Article
- Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling.The Journal of biological chemistry · 2013Article
- SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains.PloS one · 2013Article
- β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP.Journal of neurophysiology · 2012Article
- Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity.PloS one · 2011Article
- Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.Frontiers in neuroanatomy · 2011Article
- 'Silent' priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors.Cellular signalling · 2010Review
- Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling.The EMBO journal · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Glutamatergic synaptic transmission is mediated primarily through the AMPA-type glutamate receptor (AMPAR); the regulation of this receptor underlies many forms of synaptic plasticity. In particular, phosphorylation of GluR1, an AMPAR subunit, by PKA at serine 845 (S845) increases peak open channel probability and is permissive for both the synaptic expression of the receptor and NMDA-receptor (NMDAR)-dependent long-term potentiation (LTP). Robust NMDAR activation activates PKA as well as other signaling enzymes; however, we find that maximal NMDAR activation dephosphorylates GluR1 at the PKA site S845. Coincident inhibition of phosphatases blocks NMDAR-induced dephosphorylation of S845, but surprisingly does not promote PKA phosphorylation at this site. However, we find that phosphorylation of S845 is increased by the activation of a Gs-coupled receptor, the beta1-adrenergic receptor. Interestingly, this divergent signaling occurs despite a more robust coupling of the NMDAR to cAMP generation. In addition, NMDAR activation plays a dominant role in S845 regulation, because activation of beta1AR after NMDAR activation has no detectable effect on S845 phosphorylation. These data (1) demonstrate highly specific coupling between these receptors and this substrate, (2) provide an example of a substrate critical in NMDAR-dependent LTP that is incompletely regulated by the NMDAR, and (3) highlight the importance of identifying the physiological signals that regulate these critical synaptic substrates.
Indexed as
Identifiers
12843287PMC6741229W1596299456What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.