ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 126 citations in OpenAlex.
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- In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.Nature communications · 2024Article
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- Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.PLoS computational biology · 2020Article
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- The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape.Advanced biosystems · 2019Article
- Simultaneous dendritic voltage and calcium imaging and somatic recording from Purkinje neurons in awake mice.Nature communications · 2018Article
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
- Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1.PloS one · 2018Article
- Purkinje Cell Signaling Deficits in Animal Models of Ataxia.Frontiers in synaptic neuroscience · 2018Review
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Physiological reviews · 2017Review
- Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster.BMC neuroscience · 2015Article
- Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Kv3.4 channel function and dysfunction in nociceptors.Channels (Austin, Tex.) · 2015Article
- Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.Frontiers in cellular neuroscience · 2015Article
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- Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We characterized the properties and functional roles of voltage-dependent potassium channels in the dendrites of Purkinje neurons studied in rat cerebellar slices. Using outside-out patches formed <or=250 microm away from the soma, we found that depolarization-activated potassium channels were present at high density throughout the dendritic tree. Currents required relatively large depolarizations for activation (midpoint, approximately -10 mV), had rapid activation and deactivation kinetics, and inactivated partially (20-70% over 200 msec) with both fast (time constant, 15-20 msec) and slow (300-400 msec) components. Inactivating and noninactivating components were both blocked potently by external tetraethylammonium (half-block by 150 microm) and 4-aminopyridine (half-block by 110 microm). The voltage dependence, kinetics, and pharmacology suggest a predominant contribution by Kv3 family subunits, and immunocytochemical experiments showed staining for both Kv3.3 and Kv3.4 subunits in the dendritic tree. In the proximal dendrite, potassium channels were activated by passively spread sodium spikes recorded at the same position, and experiments using dual recordings showed that the channels serve to actively dampen back-propagation of somatic sodium spikes. In more distal dendrites, potassium currents were activated by voltage waveforms taken from climbing fiber responses, suggesting that they help shape these responses as well. The requirement for large depolarizations allows dendritic Kv3 channels to shape large depolarizing events while not disrupting spatial and temporal summation of smaller excitatory postsynaptic potentials.
Indexed as
Identifiers
12843273PMC6741279W1484102060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.