ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
The role of ErbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 89 citations in OpenAlex.
- Glial interactions in the formation and plasticity of the corpus callosum.Frontiers in cellular neuroscience · 2025Review
- Revisiting the role of ErbBs in oligodendrocyte development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanisms of Diseases Associated with Mutation in GJC2/Connexin 47.Biomolecules · 2023Review
- Age-specific impacts of nicotine and withdrawal on hippocampal neuregulin signalling.The European journal of neuroscience · 2022Article
- Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.Frontiers in cellular neuroscience · 2022Review
- Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Unraveling Myelin Plasticity.Frontiers in cellular neuroscience · 2020Review
- Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain.The Journal of comparative neurology · 2017Article
- Associations between pathologic tumor features and preadjuvant therapy cognitive performance in women diagnosed with breast cancer.Cancer medicine · 2017Article
- Erythropoietin Increases Myelination in Oligodendrocytes: Gene Expression Profiling Reveals Early Induction of Genes Involved in Lipid Transport and Metabolism.Frontiers in immunology · 2017Article
- Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis.Neuropharmacology · 2016Review
- Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration.Frontiers in molecular neuroscience · 2016Review
- Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders.Neural plasticity · 2015Review
- Oligodendrogenesis in the normal and pathological central nervous system.Frontiers in neuroscience · 2014Review
- Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.PLoS biology · 2013Article
- Signaling mechanisms regulating myelination in the central nervous system.Neuroscience bulletin · 2013Article
- A critical period for social experience-dependent oligodendrocyte maturation and myelination.Science (New York, N.Y.) · 2012Article
- Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy.Future oncology (London, England) · 2012Review
- Gap junctions in inherited human disorders of the central nervous system.Biochimica et biophysica acta · 2012Review
- On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter?Journal of neuropathology and experimental neurology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The knock-out analyses of neuregulin and its receptors have indicated that they play essential roles in Schwann cell development. However, the role they play in oligodendrocyte development in vivo has remained unclear, because such knock-out animals die before CNS myelination begins. We examined the role of neuregulin signaling in the CNS by generating transgenic mice that express a dominant-negative mutant of the ErbB2 receptor among oligodendrocytes, using an MBP promoter. The transgenic mice exhibited widespread hypomyelination, resulting from a reduction in oligodendrocyte differentiation. The number of progenitors was conversely increased in the transgenic mice. We report that a reduction in oligodendrocyte differentiation is attributed in part to apoptosis of oligodendrocyte progenitors as they exit the cell cycle. A significant reduction in the number of p27+ oligodendrocyte precursors in the transgenic mice supports this conclusion. Taken together, these data suggest that for oligodendrocyte progenitors, ErbB2 signaling plays a role in governing a properly timed exit from the cell cycle during development into myelinating oligodendrocytes.
Indexed as
Identifiers
12843257PMC6741253W2128979512What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.