ArticleJournal of clinical microbiology2003
Widespread pyrazinamide-resistant Mycobacterium tuberculosis family in a low-incidence setting.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review.BMC medicine · 2018Pooled it
- Effects of Host, Sample, andFrontiers in genetics · 2019Article
- Global expansion ofScience advances · 2018Article
- Phenotypic and genotypic drug sensitivity ofInfection and drug resistance · 2018Article
- Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.BMC microbiology · 2016Article
- Outbreak of pyrazinamide-monoresistant tuberculosis identified using genotype cluster and social media analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014Article
- Gene sequencing for routine verification of pyrazinamide resistance in Mycobacterium tuberculosis: a role for pncA but not rpsA.Journal of clinical microbiology · 2012Article
- Pharmacokinetics-pharmacodynamics of pyrazinamide in a novel in vitro model of tuberculosis for sterilizing effect: a paradigm for faster assessment of new antituberculosis drugs.Antimicrobial agents and chemotherapy · 2009Article
- Spoligotype signatures in the Mycobacterium tuberculosis complex.Journal of clinical microbiology · 2007Article
- Sensitivities and specificities of spoligotyping and mycobacterial interspersed repetitive unit-variable-number tandem repeat typing methods for studying molecular epidemiology of tuberculosis.Journal of clinical microbiology · 2005Article
- Genomic characterization of an endemic Mycobacterium tuberculosis strain: evolutionary and epidemiologic implications.Journal of clinical microbiology · 2004Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An unusually high prevalence of pyrazinamide (PZA) monoresistance in Mycobacterium tuberculosis has been observed in Quebec. In the absence of a recognized outbreak, we hypothesized that these isolates most likely represented reactivation of an old endemic strain in this low-incidence area. A case-control study of 77 PZA-resistant isolates with a specific Quebec mutation and 253 PZA-susceptible control M. tuberculosis isolates was undertaken. By molecular analysis, all 77 case isolates shared a unique mutation profile in the pncA gene which was not present in control isolates. While control isolates manifested diverse IS6110 restriction fragment length polymorphism (RFLP) patterns, spoligotypes, and major genetic groups, case isolates had similar but nonidentical IS6110 RFLP patterns, had common spoligotypes, and were confined to one major genetic group, suggesting a common clonal ancestor. By epidemiologic and geographic analyses, however, there were no significant differences between the cases and the controls. We conclude that a clonally related family of PZA-monoresistant M. tuberculosis isolates in Quebec represents historic rather than recent transmission.
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