ArticleBMJ (Clinical research ed.)2003
Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs.
Article in BMJ (Clinical research ed.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.
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- Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project.PloS one · 2020Article
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- Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials.International journal of hepatology · 2018Review
- Antidepressant-Induced Acute Liver Injury: A Case-Control Study in an Italian Inpatient Population.Drug safety · 2018Article
- Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines.Nature communications · 2017Article
- Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases.Drug safety · 2017Article
- Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs.
designRetrospective cohort and nested case-control study.
settingUmbria region, Italy.
participants400 000 current, recent, and past users (almost 2 million prescriptions) of non-steroidal anti-inflammatory drugs between 1 January 1997 and 31 December 2001.
main outcome measuresAdmissions to hospital for acute non-viral hepatitis and incidence of all hepatopathies and liver injury among users of nimesulide and other non-steroidal anti-inflammatory drugs.
resultsCurrent use of non-steroidal anti-inflammatory drugs was associated with a 1.4 (95% confidence interval 1.0 to 2.1) increased risk of hepatopathy compared with past use. In current users of nimesulide the rate ratio for all hepatopathies and more severe liver injury was 1.3 (0.7 to 2.3) and 1.9 (1.1 to 3.8), respectively.
conclusionThe risk of liver injury in patients taking nimesulide and other non-steroidal anti-inflammatory drugs is small.
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