ArticleThe Biochemical journal2003
The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- The Transcription Factor Otc4A Stimulates the Proliferation, Invasion, and Stemness of Colorectal Cancer Cells by Inhibiting the Regulation of miR-7-5p on TLR4.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients.Cells · 2021Article
- OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells.Oncology letters · 2018Article
- Upregulated SLC22A3 has a potential for improving survival of patients with head and neck squamous cell carcinoma receiving cisplatin treatment.Oncotarget · 2017Article
- Distinctive expression pattern of OCT4 variants in different types of breast cancer.Cancer biomarkers : section A of Disease markers · 2017Article
- Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF‑7 cells by reducing FGF4 protein expression.Molecular medicine reports · 2016Article
- Cancer stem cells--the current status of an old concept: literature review and clinical approaches.Biological research · 2014Review
- OCT3/4 expression is correlated with the invasion of gastric carcinoma.Oncology letters · 2014Article
- Downregulation of KPNA2 in non-small-cell lung cancer is associated with Oct4 expression.Journal of translational medicine · 2013Article
- Fluorouracil selectively enriches stem-like cells in the lung adenocarcinoma cell line SPC.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Octamer-binding transcription factors: genomics and functions.Frontiers in bioscience (Landmark edition) · 2013Review
- Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog.PloS one · 2013Article
- Genetic architecture of body size in mammals.Genome biology · 2012Review
- Differential expression profiling between atypical teratoid/rhabdoid and medulloblastoma tumor in vitro and in vivo using microarray analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2010Article
- EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours.British journal of cancer · 2010Article
- P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.Oncogene · 2009Article
- Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells.PloS one · 2008Article
- The EWS-Oct-4 fusion gene encodes a transforming gene.The Biochemical journal · 2007Article
- Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration.Gastroenterology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The POU (representing a homeodomain protein family of which the founder members are Pit-1, Oct-1/2 and Unc-86) homeodomain protein OCT3/Oct-3 (where OCT stands for octamer-binding protein) is an embryonic transcription factor expressed in oocytes, embryonic stem and embryonic carcinoma cells. We have demonstrated previously that human breast cancer cells regain the ability to express OCT3 mRNA [Jin, Branch, Zhang, Qi, Youngson and Goss (1999) Int. J. Cancer 81, 104-112]. Antibodies against human OCT3 were not available when this study was conducted. By using a human OCT3-glutathione S-transferase fusion protein to affinity purify a polyclonal antibody against the mouse Oct-3, we obtained an antibody that enabled us to detect OCT3 in human breast cancer cells by Western-blot analysis. Thus we have now confirmed that OCT3 is expressed in human breast cancer cells but not in normal human breasts and in three other organs. When breast cancer cell lines were treated with all- trans -retinoic acid, OCT3 expression was repressed, associated with decreased cell proliferation. Although another POU protein Brn-3 has been shown to be a repressor for BRCA1 (breast-cancer susceptibility gene 1), OCT3 does not repress human or mouse BRCA1/Brca-1 promoters. However, OCT3 is capable of activating a fusion promoter containing the fibroblast growth factor-4 (FGF-4) enhancer element. In addition, we documented for the first time that human breast cancer cells express FGF-4 protein, and its expression could be inhibited by all- trans -retinoic acid. Furthermore, overexpressing OCT3 stimulated endogenous FGF-4 expression in MCF7 breast cancer cell line. These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression.
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