ArticleMolecular and cellular biochemistry2003
Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction.
Article in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease.Antioxidants & redox signaling · 2021Review
- Anti-Vascular Inflammatory Effect of Ethanol Extract fromNutrients · 2020Article
- Coronary Microvascular Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Artery Disease Is Associated With Elevated Serum Homocysteine Levels.Journal of the American Heart Association · 2020Article
- Elevated plasma homocysteine levels are associated with impaired peripheral microvascular vasomotor response.International journal of cardiology. Heart & vasculature · 2020Article
- Coronary flow velocity reserve is impaired in hypertensive patients with hyperhomocysteinemia.Journal of human hypertension · 2014Article
- Homocysteine in renovascular complications: hydrogen sulfide is a modulator and plausible anaerobic ATP generator.Nitric oxide : biology and chemistry · 2014Review
- Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease.EMBO molecular medicine · 2014Review
- Homocysteine, Paraoxonase-1 and Vascular Endothelial Dysfunction: Omnibus viis Romam Pervenitur.Journal of clinical and diagnostic research : JCDR · 2014Review
- Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.PloS one · 2014Article
- Isolation, purification, and identification of an important pigment, sepiapterin, from integument of the lemon mutant of the silkworm, Bombyx mori.Journal of insect science (Online) · 2013Article
- Hyperhomocysteinemia and Endothelial Dysfunction.Current hypertension reviews · 2009Article
- Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.Arteriosclerosis, thrombosis, and vascular biology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homocysteine is an independent risk factor for atherosclerotic vascular disease. It impairs endothelial function via increasing superoxide production and quenching nitric oxide (NO) release. Tetrahydrobiopterin (BH4) is a critical cofactor that couples nitric oxide synthase and facilitates the production of nitric oxide (vs. superoxide anions). In the first study, the effects of hyperhomocysteinemia (0.1 mM, 3 h) on endothelium-dependent vasorelaxation to ACh and A23187 were examined in isolated segments of rat aortae in the presence or absence of BH4 (0.1 mM). In the second study, the effects of hyperhomocysteinemia (24 h) on nitric oxide production and superoxide release (using lucigenin chemiluminescence) were studied in human umbilical vein endothelial cells in the absence or presence of BH4 (10 microM). Homocysteine incubation impaired receptor-dependent and -independent endothelial function to ACh and A23187. This effect was attenuated by BH4. Furthermore, homocysteine exposure increased superoxide production and impaired agonist-stimulated nitric oxide release. These effects were attenuated by BH4 (p < 0.05). Hyperhomocysteinemia impairs endothelial function, in part due to a diminished bioavailability of BH4 with resultant uncoupling of nitric oxide synthase. BH4 may represent an important target for strategies aimed at improving endothelial dysfunction secondary to hyperhomocysteinemia.
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