ArticleThe EMBO journal2003
Complex mechanism of site-specific DNA replication termination in fission yeast.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023Review
- Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.PLoS genetics · 2016Article
- Article
- The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.PloS one · 2015Article
- The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.Journal of cell science · 2014Article
- Establishment of a replication fork barrier following induction of DNA binding in mammalian cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.PloS one · 2013Article
- The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.Genes & development · 2012Article
- Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.Nucleic acids research · 2011Article
- Leaping forks at inverted repeats.Genes & development · 2010Article
- Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism.Genes & development · 2009Article
- Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.Molecular and cellular biology · 2008Article
- Article
- Replication fork stalling at natural impediments.Microbiology and molecular biology reviews : MMBR · 2007Review
- Replication-associated strand asymmetries in mammalian genomes: toward detection of replication origins.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A site-specific replication terminator, RTS1, is present at the Schizosaccharomyces pombe mating-type locus mat1. RTS1 regulates the direction of replication at mat1, optimizing mating-type switching that occurs as a replication-coupled recombination event. Here we show that RTS1 contains two cis-acting sequences that cooperate for efficient replication termination. First, a sequence of approximately 450 bp containing four repeated 55 bp motifs is essential for function. Secondly, a purine-rich sequence of approximately 60 bp without intrinsic activity, located proximal to the repeats, acts cooperatively to increase barrier activity 4-fold. Our data suggest that the trans-acting factors rtf1p and rtf2p act through the repeated motifs and the purine-rich element, respectively. Thus, efficient site-specific replication termination at RTS1 occurs by a complex mechanism involving several cis-acting sequences and trans-acting factors. Interestingly, RTS1 displays similarities to mammalian rDNA replication barriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.