ArticleBritish journal of pharmacology2003
Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
- Serotonergic dysfunction in patients with impulse control disorders in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI.Progress in neurobiology · 2024Article
- Genetic polymorphism in HTR2A rs6313 is associated with internet addiction disorder.Frontiers in psychiatry · 2024Article
- Learned Helplessness As a Potential Transdiagnostic Therapeutic Mechanism of Classic Psychedelics.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- Environmentally-relevant concentrations of the antipsychotic drugs sulpiride and clozapine induce abnormal dopamine and serotonin signaling in zebrafish brain.Scientific reports · 2022Article
- A Complex Impact of Systemically Administered 5-HT2A Receptor Ligands on Conditioned Fear.The international journal of neuropsychopharmacology · 2021Article
- Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice.IBRO neuroscience reports · 2021Article
- Lorcaserin Alters Serotonin and Noradrenaline Tissue Content and Their Interaction With Dopamine in the Rat Brain.Frontiers in pharmacology · 2020Article
- Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence.CNS neuroscience & therapeutics · 2018Article
- Positive regulation of raphe serotonin neurons by serotonin 2B receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Serotonin and brain function: a tale of two receptors.Journal of psychopharmacology (Oxford, England) · 2017Review
- Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?Frontiers in pharmacology · 2015Review
- A group of non-serotonergic cells is CO2-stimulated in the medullary raphé.Neuroscience · 2014Article
- Comparison of female Fischer and Sprague-Dawley rats in the response to ketanserin.Pharmacology, biochemistry, and behavior · 2013Article
- Systemic inflammation alters central 5-HT function as determined by pharmacological MRI.NeuroImage · 2013Article
- 5-HT₂A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system.Experimental brain research · 2013Article
- Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.The journal of physiological sciences : JPS · 2013Article
- Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved.Frontiers in pharmacology · 2013Article
- Reduced activity at the 5-HT(2C) receptor enhances reversal learning by decreasing the influence of previously non-rewarded associations.Psychopharmacology · 2012Article
- A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Systemic administration of phenethylamine-derived, 5-hydroxytryptamine(2) (5-HT(2)) receptor agonists inhibits the firing of midbrain 5-HT neurones, but the 5-HT receptors involved are poorly defined, and the contribution of peripheral mechanisms is uncertain. This study addresses these issues using extracellular recordings of 5-HT neurones in the dorsal raphe nucleus of anaesthetised rats. 2. The 5-HT(2) receptor agonists DOI ((+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride) and DOB ((+/-)-2,5-dimethoxy-4-bromoamphetamine hydrobromide), caused a dose-related (10-100 micro g kg(-1) i.v.) inhibition of 5-HT neuronal activity, with the highest dose reducing firing rates by >80%. 3. Pretreatment with the 5-HT(2) receptor antagonist ritanserin (1 mg kg(-1) i.v.) completely blocked the action of DOI. The 5-HT(2A) receptor antagonist MDL 100,907 (0.2 mg kg(-1) i.v.) blocked the action of both DOI and DOB. In comparison, the 5-HT(2B/C) receptor antagonist SB 206553 (0.5 mg kg(-1) i.v.) caused a small, but statistically significant, shift to the right in the dose response to DOI and DOB. 4. Pretreatment with the peripherally acting 5-HT(2) receptor antagonist BW 501C67 (0.1 mg kg(-1) i.v.) had no effect on the DOI-induced inhibition of 5-HT cell firing, but completely blocked the DOI-induced rise in mean arterial blood pressure. 5. These data indicate that the inhibition of 5-HT cell firing induced by systemic administration of DOI and DOB is mediated predominantly by the 5-HT(2A) receptor-subtype, but that 5-HT(2B/C) receptors also play a minor role. Moreover, central and not peripheral mechanisms are involved. Given evidence that 5-HT(2) receptors are not located on 5-HT neurones, postsynaptic 5-HT feedback mechanisms are implicated.
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