ArticleBritish journal of pharmacology2003
Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Role of transient receptor potential channels in the regulation of vascular tone.Drug discovery today · 2024Review
- Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Effects of cell seeding density on real-time monitoring of anti-proliferative effects of transient gene silencing.Journal of biological research (Thessalonike, Greece) · 2016Article
- Reduction of blood pressure by store-operated calcium channel blockers.Journal of cellular and molecular medicine · 2015Article
- G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.Pflugers Archiv : European journal of physiology · 2014Article
- Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.BMC neuroscience · 2014Article
- Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer.PloS one · 2013Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Orai1 calcium channels in the vasculature.Pflugers Archiv : European journal of physiology · 2012Review
- S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.American journal of physiology. Cell physiology · 2011Article
- Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes.British journal of pharmacology · 2010Article
- Store-operated Ca(2+) entry is not essential for PDGF-BB induced phenotype modulation in rat aortic smooth muscle.Cell calcium · 2010Article
- The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.The Journal of biological chemistry · 2010Article
- Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Store-operated calcium entry in vascular smooth muscle.British journal of pharmacology · 2008Review
- TRP channels in hypertension.Biochimica et biophysica acta · 2007Review
- Non-selective cation channels, transient receptor potential channels and ischemic stroke.Biochimica et biophysica acta · 2007Review
- A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.Circulation research · 2006Article
- Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect.British journal of pharmacology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. In this study, we determined a pharmacological profile of store-operated channels (SOCs) in smooth muscle cells of rabbit pial arterioles. Ca(2+)-indicator dyes, fura-PE3 or fluo-4, were used to track [Ca(2+)](i) and 10 micro M methoxyverapamil (D600) was present in all experiments on SOCs to prevent voltage-dependent Ca(2+) entry. Store depletion was induced using thapsigargin or cyclopiazonic acid. 2. SOC-mediated Ca(2+) entry was inhibited concentration dependently by Gd(3+) (IC(50) 101 nM). It was also inhibited by 10 micro M La(3+) (70% inhibition, N=5), 100 micro M Ni(2+) (57% inhibition, N=5), 75 micro M 2-aminoethoxydiphenylborate (66% inhibition, N=4), 100 micro M capsaicin (12% inhibition, N=3) or preincubation with 10 micro M wortmannin (76% inhibition, N=4). It was completely resistant to 1 micro M nifedipine (N=5), 10 micro M SKF96365 (N=6), 10 micro M LOE908 (N=14), 10-100 micro M ruthenium red (N=1+2), 100 micro M sulindac (N=4), 0.5 mM streptomycin (N=3) or 1 : 10,000 dilution Grammostolla spatulata venom (N=4). 3. RT-PCR experiments on isolated arteriolar fragments showed expression of mRNA species for TRPC1, 3, 4, 5 and 6. 4. The pharmacological profile of SOC-mediated Ca(2+) entry in arterioles supports the hypothesis that these SOCs are distinct from tonically active background channels and several store-operated and other nonselective cation channels described in other cells. Similarities with the pharmacology of TRPC1 support the hypothesis that TRPC1 is a subunit of the arteriolar smooth muscle SOC.
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