ArticleThe Journal of membrane biology1992
Calcium-independent K(+)-selective channel from chromaffin granule membranes.
Article in The Journal of membrane biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular requirements of chromogranin B for the long-sought anion shunter of regulated secretion.International journal of biological macromolecules · 2025Article
- Cellular functions of transient receptor potential channels.The international journal of biochemistry & cell biology · 2010Review
- Exocytotic catecholamine release is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore.Nature cell biology · 2007Article
- The heterogeneity of ion channels in chromaffin granule membranes.Cellular & molecular biology letters · 2006Article
- Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms.The Biochemical journal · 2001Article
- Similarity in calcium channel activity of annexin V and matrix vesicles in planar lipid bilayers.Biophysical journal · 1996Article
- Direct control of a large conductance K(+)-selective channel by G-proteins in adrenal chromaffin granule membranes.The Journal of membrane biology · 1995Article
- The non-specific ion channel in Torpedo ocellata fused synaptic vesicles.The Journal of physiology · 1995Article
- Evidence for a K+ channel in bovine chromaffin granule membranes: single-channel properties and possible bioenergetic significance.European biophysics journal : EBJ · 1994Article
- Patch clamp studies of single intact secretory granules.Biophysical journal · 1993Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intact adrenal chromaffin granules and purified granule membrane ghosts were allowed to fuse with acidic phospholipid planar bilayer membranes in the presence of Ca2+ (1 mM). From both preparations, we were able to detect a large conductance potassium channel (ca. 160 pS in symmetrical 400 mM K+), which was highly selective for K+ over Na+ (PK/PNa = 11) as estimated from the reversal potential of the channel current. Channel activity was unaffected by charybdotoxin, a blocker of the [Ca2+]-activated K+ channel of large conductance. Furthermore, this channel proved quite different from the previously described channels from other types of secretory vesicle preparations, not only in its selectivity and conductance, but also in its insensitivity to both calcium and potential across the bilayer. We conclude that the chromaffin granule membrane contains a K(+)-selective channel with large conductance. We suggest that the role of this channel may include ion movement during granule assembly or recycling, and do not rule out events leading to exocytosis.
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