ArticleApplied and environmental microbiology2003
Identification of a new ribosomal protection type of tetracycline resistance gene, tet(36), from swine manure pits.
Article in Applied and environmental microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Metagenomic Comparison of Bat Colony Resistomes Across Anthropogenic and Pristine Habitats.Antibiotics (Basel, Switzerland) · 2026Article
- Department-specific patterns of bacterial communities and antibiotic resistance in hospital indoor environments.Applied microbiology and biotechnology · 2024Article
- Comparison of antibiotic resistance genes in swine manure storage pits of Iowa, USA.Frontiers in antibiotics · 2023Article
- Predicting the re-distribution of antibiotic molecules caused by inter-species interactions in microbial communities.ISME communications · 2022Article
- The distribution of microbiomes and resistomes across farm environments in conventional and organic dairy herds in Pennsylvania.Environmental microbiome · 2020Article
- Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events.Veterinary sciences · 2020Review
- Article
- Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.Cell host & microbe · 2018Article
- High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application.Scientific reports · 2018Article
- Characterization and Comparative Overview of Complete Sequences of the First Plasmids ofFrontiers in microbiology · 2016Article
- Chlortetracycline-resistant intestinal bacteria in organically raised and feral Swine.Applied and environmental microbiology · 2011Article
- Article
- Impact of an aerobic thermophilic sequencing batch reactor on antibiotic-resistant anaerobic bacteria in swine waste.Microbial ecology · 2009Article
- Tetracycline-associated transcriptional regulation of transfer genes of the Bacteroides conjugative transposon CTnDOT.Journal of bacteriology · 2009Article
- Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs.Journal of applied oral science : revista FOBReview
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Authors and funding
6 authors.
Funding
Abstract
Previously, only one ribosome protection type of a tetracycline resistance gene, tetQ, had been identified in Bacteroides spp. During an investigation of anaerobic bacteria present in swine feces and manure storage pits, a tetracycline-resistant Bacteroides strain was isolated. Subsequent analysis showed that this new Bacteroides strain, Bacteroides sp. strain 139, did not contain tetQ but contained a previously unidentified tetracycline resistance gene. Sequence analysis showed that the tetracycline resistance gene from Bacteroides sp. strain 139 encoded a protein (designated Tet 36) that defines a new class of ribosome protection types of tetracycline resistance. Tet 36 has 60% amino acid identity over 640 aa to TetQ and between 31 and 49% amino acid identity to the nine other ribosome protection types of tetracycline resistance genes. The tet(36) region was not observed to transfer from Bacteroides sp. strain 139 to another Bacteroides sp. under laboratory conditions. Yet tet(36) was found in other genera of bacteria isolated from the same swine manure pits and from swine feces. Phylogenetic analysis of the tet(36)-containing isolates indicated that tet(36) was present not only in the Cytophaga-Flavobacter-Bacteroides group to which Bacteroides sp. strain 139 belongs but also in gram-positive genera and gram-negative proteobacteria, indicating that horizontal transfer of tet(36) is occurring between these divergent phylogenetic groups in the farm environment.
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