ArticlePflugers Archiv : European journal of physiology2003
Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Cancer therapy-related salivary dysfunction.The Journal of clinical investigation · 2024Review
- The Role of Uroguanylin in Regulation of Ion Transport in Salivary Glands.Acta stomatologica Croatica · 2023Article
- Review
- Aquaporins in Glandular Secretion.Advances in experimental medicine and biology · 2023Article
- Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development.Journal of anatomy · 2021Article
- Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.BioMed research international · 2021Article
- Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions.Journal of clinical medicine · 2020Review
- Physiological and pathophysiological role of ion channels and transporters in the colorectum and colorectal cancer.Journal of cellular and molecular medicine · 2020Review
- Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions.International journal of molecular sciences · 2020Review
- Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands.FEBS open bio · 2018Article
- The expression of water channel proteins during human salivary gland development: a topographic study of aquaporins 1, 3 and 5.Journal of molecular histology · 2017Article
- Runx1 mediates the development of the granular convoluted tubules in the submandibular glands.PloS one · 2017Article
- Physiological role of aquaporin 5 in salivary glands.Pflugers Archiv : European journal of physiology · 2016Review
- Aquaporins in Salivary Glands: From Basic Research to Clinical Applications.International journal of molecular sciences · 2016Review
- Aquaporins in the adult mouse submandibular and sublingual salivary glands.Journal of molecular histology · 2014Article
- Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats.Scientific reports · 2013Article
- Aquaporin 5 distribution pattern during development of the mouse sublingual salivary gland.Journal of molecular histology · 2011Article
- Localization of AQP5 during development of the mouse submandibular salivary gland.Journal of molecular histology · 2011Article
- Altered expression of sodium transporters and water channels in the submandibular gland of rats treated with nitric oxide synthesis inhibitors.Electrolyte & blood pressure : E & BP · 2008Article
- Role of bone marrow-derived mesenchymal stem cells on the parotid glands of streptozotocin induced diabetes rats.Journal of oral biology and craniofacial researchArticle
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Authors and funding
8 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression and localization of aquaporins (AQP1-AQP5), members of the water channel family, in the developing rat submandibular gland were analysed using RT-PCR, Northern blotting and immunohistochemistry to explore their relation to the development of this salivary gland. RT-PCR analysis revealed unique expression patterns of each AQP. AQP1 was expressed constitutively during prenatal development, whereas the expression of AQP5 became more intense in the course of development from embryonic day 16.5 (E16) to E20. These expression patterns concurred with the results of Northern blot analysis. AQP3 and AQP4 mRNAs in the prenatal development were not detected in Northern blots, although they were detected by RT-PCR. During postnatal development, AQP5 and AQP1 mRNAs were expressed continuously, but no message for AQP3 or AQP4 was detected. AQP2 mRNA was not detected during either prenatal or postnatal development in this tissue. Immunohistochemical studies revealed that AQP5 was first localized at the apical membrane of proacinar cells at E18, and then became clearly distributed at the apical membrane of acinar cells in accordance with the differentiation and establishment of the mature acini. In addition, some vasculature also showed immunoreactivity for AQP5. AQP1 was immunolocalized in the blood vessels, including capillaries, of the gland throughout development. These observations suggest the existence of transcriptional regulation of rat AQP5, which is one of the most probable regulators of saliva production and secretion, during the establishment of the functional submandibular salivary gland.
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