ReviewJournal of structural and functional genomics2003
Crystallin genes: specialization by changes in gene regulation may precede gene duplication.
Review in Journal of structural and functional genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- Moonlighting enzymes: when cellular context defines specificity.Cellular and molecular life sciences : CMLS · 2023Review
- Adaptation and Exaptation: From Small Molecules to Feathers.Journal of molecular evolution · 2022Article
- Crystallin gene expression: Insights from studies of transcriptional bursting.Experimental eye research · 2021Review
- Three overlooked key functional classes for building up minimal synthetic cells.Synthetic biology (Oxford, England) · 2021Article
- Molecular cloning, antiserum preparation and expression analysis during head regeneration of α-crystallin type heat shock protein inJournal of genetics · 2018Article
- Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina.Journal of ginseng research · 2016Article
- Article
- Lens Biology and Biochemistry.Progress in molecular biology and translational science · 2015Review
- Genome-scale identification and characterization of moonlighting proteins.Biology direct · 2014Article
- Structure and identification of a pterin dehydratase-like protein as a ribulose-bisphosphate carboxylase/oxygenase (RuBisCO) assembly factor in the α-carboxysome.The Journal of biological chemistry · 2014Article
- Earliest Holozoan expansion of phosphotyrosine signaling.Molecular biology and evolution · 2014Article
- Extracellular enolase of Candida albicans is involved in colonization of mammalian intestinal epithelium.Frontiers in cellular and infection microbiology · 2014Article
- Optimisations and evolution of the mammalian respiratory system : A suggestion of possible gene sharing in evolution.The European physical journal. E, Soft matter · 2013Article
- Divergence and convergence in enzyme evolution.The Journal of biological chemistry · 2012Review
- Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs.Molecular vision · 2012Article
- The lens in focus: a comparison of lens development in Drosophila and vertebrates.Molecular genetics and genomics : MGG · 2011Review
- Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- beta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallin.Protein science : a publication of the Protein Society · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crystallins account for 80-90% of the water-soluble proteins of the transparent lens. These diverse proteins are responsible for the optical properties of the lens and have been recruited from metabolic enzymes and stress proteins. They often differ among species (i.e. are taxon-specific) and may be expressed outside of the lens where they have non-refractive roles (a situation we call gene sharing). Crystallin recruitment has occurred by changes in gene regulation resulting in high lens expression. Duck lactate dehydrogenase/epsilon-crystallin and alpha-enolase/tau-crystallin are each encoded in single-copy genes, consistent with these enzymes acquiring a crystallin role, without loss of their nonlens metabolic function, by a change in gene regulation in the absence of gene duplication. The small heat shock protein/alpha-crystallins and avian argininosuccinate lyase/delta-crystallins were also recruited by a change in gene regulation leading to high lens expression, except this was followed by a gene duplication with further lens specialization of the alphaA and the delta1 (in chickens) crystallin genes. Cephalopod (squid and octopus) S-crystallins were recruited from glutathione S-transferase apparently after duplication of the original gene encoding the enzyme, although this remains uncertain. We speculate that one of the new genes (glutathione S-transferase/S11-crystallin) specialized for lens expression by a change in gene regulation and subsequently duplicated many times to form the lens-specialized, multiple S-crystallins that lack enzymatic activity. That similar transcription factors (e.g. Pax-6, retinoic acid receptors, maf, Sox, AP-1, CREB) regulate different crystallin genes suggest that common features of lens-specific expression have played a pivotal role for recruiting the diverse, multifunctional proteins as crystallins.
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12836692W1571987077What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.