ReviewJournal of structural and functional genomics2003
The 2R hypothesis and the human genome sequence.
Review in Journal of structural and functional genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica.The New phytologist · 2026Article
- Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia.PLoS biology · 2025Article
- Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor.Nature communications · 2023Article
- Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells.The Biochemical journal · 2022Article
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Analysis of Paralogons, Origin of the Vertebrate Karyotype, and Ancient Chromosomes Retained in Extant Species.Genome biology and evolution · 2021Article
- Fibrillarin evolution through the Tree of Life: Comparative genomics and microsynteny network analyses provide new insights into the evolutionary history of Fibrillarin.PLoS computational biology · 2020Article
- Deeply conserved synteny resolves early events in vertebrate evolution.Nature ecology & evolution · 2020Article
- Phylogenetic analyses of human 1/2/8/20 paralogons suggest segmental duplications during animal evolution.3 Biotech · 2019Article
- Article
- Network-based microsynteny analysis identifies major differences and genomic outliers in mammalian and angiosperm genomes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolution of the vertebrate insulin receptor substrate (Irs) gene family.BMC evolutionary biology · 2017Article
- Expansion by whole genome duplication and evolution of the sox gene family in teleost fish.PloS one · 2017Article
- An evolutionary roadmap to the microtubule-associated protein MAP Tau.BMC genomics · 2016Article
- Analysis of the reptile CD1 genes: evolutionary implications.Immunogenetics · 2015Article
- Evolution, functional divergence and conserved exon-intron structure of bHLH/PAS gene family.Molecular genetics and genomics : MGG · 2014Article
- Computational characterization of modes of transcriptional regulation of nuclear receptor genes.PloS one · 2014Article
- Evolution of glucose utilization: glucokinase and glucokinase regulator protein.Molecular phylogenetics and evolution · 2014Review
- Duplication and maintenance of the Myb genes of vertebrate animals.Biology open · 2013Article
- A graph-theoretic approach for inparalog detection.BMC bioinformatics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One theory formalised in 1970 proposes that the complexity of vertebrate genomes originated by means of genome duplication at the base of the vertebrate lineage. Since then, the theory has remained both popular and controversial. Here we review the theory, and present preliminary results from our analysis of duplications in the draft human genome sequence. We find evidence for extensive duplication of parts of the genome. We also question the validity of the 'parsimony test' that has been used in other analyses.
Indexed as
Identifiers
12836689What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.