ReviewJournal of structural and functional genomics2003
More genes in vertebrates?
Review in Journal of structural and functional genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Functional assays inGenome research · 2025Review
- A Comprehensive Analysis of the DUF4228 Gene Family inInternational journal of molecular sciences · 2022Article
- Horseshoe crab genomes reveal the evolution of genes and microRNAs after three rounds of whole genome duplication.Communications biology · 2021Article
- Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates.BMC evolutionary biology · 2018Article
- Evolution of neuropeptide signalling systems.The Journal of experimental biology · 2018Review
- The mammalian skeletal muscle DHPR has larger CaCell calcium · 2017Article
- Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors.Biomolecules & therapeutics · 2017Review
- Article
- Genome-wide identification, phylogeny, and gonadal expression of fox genes in Nile tilapia, Oreochromis niloticus.Fish physiology and biochemistry · 2014Article
- Gene duplication, genome duplication, and the functional diversification of vertebrate globins.Molecular phylogenetics and evolution · 2013Review
- Drosophila melanogaster as a model to study drug addiction.Human genetics · 2012Review
- The evolutionary significance of ancient genome duplications.Nature reviews. Genetics · 2009Review
- The evolution of alternative splicing in the Pax family: the view from the Basal chordate amphioxus.Journal of molecular evolution · 2008Article
- Slipins: ancient origin, duplication and diversification of the stomatin protein family.BMC evolutionary biology · 2008Article
- Comparative phylogenomic analyses of teleost fish Hox gene clusters: lessons from the cichlid fish Astatotilapia burtoni.BMC genomics · 2007Article
- Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?BMC evolutionary biology · 2007Article
- Comparative genomics of vertebrate Fox cluster loci.BMC genomics · 2006Article
- Evolutionary genomics of the recently duplicated amphioxus Hairy genes.International journal of biological sciences · 2006Article
- The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis.Genome biology · 2006Article
- The gain and loss of genes during 600 million years of vertebrate evolution.Genome biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the acquisition of complete genome sequences from several animals, there is renewed interest in the pattern of genome evolution on our own lineage. One key question is whether gene number increased during chordate or vertebrate evolution. It is argued here that comparing the total number of genes between a fly, a nematode and human is not appropriate to address this question. Extensive gene loss after duplication is one complication; another is the problem of comparing taxa that are phylogenetically very distant. Amphioxus and tunicates are more appropriate animals for comparison to vertebrates. Comparisons of clustered homeobox genes, where gene loss can be identified, reveals a one to four mode of evolution for Hox and ParaHox genes. Analyses of other gene families in amphioxus and vertebrates confirm that gene duplication was very widespread on the vertebrate lineage. These data confirm that vertebrates have more genes than their closest invertebrate relatives, acquired through gene duplication.
Indexed as
Identifiers
12836687W1562052426What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.