ArticleEMBO reports2003
The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro.
Article in EMBO reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Influence of mindfulness-based stress reduction (MBSR) on telomerase activity in women with breast cancer (BC).Biological research for nursing · 2014Trial
- Assembly path dependence of telomeric DNA compaction by TRF1, TIN2, and SA1.Biophysical journal · 2023Article
- Non-canonical roles of canonical telomere binding proteins in cancers.Cellular and molecular life sciences : CMLS · 2021Review
- A Truncating Germline Mutation ofThyroid : official journal of the American Thyroid Association · 2020Article
- The Role of Ubiquitination and SUMOylation in Telomere Biology.Current issues in molecular biology · 2020Review
- Molecular Architecture of Full-length TRF1 Favors Its Interaction with DNA.The Journal of biological chemistry · 2016Article
- Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells.Molecular biology of the cell · 2014Article
- Structural and functional association of androgen receptor with telomeres in prostate cancer cells.Aging · 2013Article
- Telomeric armor: the layers of end protection.Journal of cell science · 2009Article
- A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix.Cell cycle (Georgetown, Tex.) · 2009Article
- Distinct roles of TRF1 in the regulation of telomere structure and lengthening.The Journal of biological chemistry · 2008Article
- Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.The Journal of cell biology · 2008Article
- A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The telomerase cycle: normal and pathological aspects.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.Journal of cell science · 2005Article
- Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis.The American journal of pathology · 2005Article
- Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.Molecular and cellular biology · 2004Article
- Function, replication and structure of the mammalian telomere.Cytotechnology · 2004Article
- Telomere attachment, meiotic chromosome condensation, pairing, and bouquet stage duration are modified in spermatocytes lacking axial elements.Molecular biology of the cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Human TIN2 interacts with the telomeric-DNA-binding protein TRF1, suppresses telomere elongation in telomerase-positive cells, and may control telomere length by modulating telomere structure. To test the latter idea, we developed an in vitro assay, using biotinylated telomeric DNA probes and streptavidin-agarose, to quantify the ability of TRF1 and TIN2 to stimulate interactions of telomeric DNA tracts with each other (probe clustering). This assay revealed that TRF1 alone had weak probe-clustering activity, but TIN2 stimulated activity fivefold to tenfold. A dominant-negative TIN2 mutant protein that increased telomere length in vivo disrupted probe clusters formed by TRF1 and TIN2, suggesting that the ability to stimulate telomeric DNA interactions is important for telomere-length regulation. Unlike TRF1, TIN2 did not form homodimers. We propose that TIN2 alters the conformation of TRF1, which favours a tertiary telomeric structure that hinders telomerase from gaining access to telomeres.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.