ArticleDevelopment (Cambridge, England)2003
Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye.
Article in Development (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Spatial regulation and generation of diversity in signaling pathways.Journal of biosciences · 2021Review
- Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation.Current biology : CB · 2019Article
- Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible.BMC genomics · 2017Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- The Conserved MAPK Site in E(spl)-M8, an Effector of Drosophila Notch Signaling, Controls Repressor Activity during Eye Development.PloS one · 2016Article
- A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.Developmental biology · 2014Article
- Stimulated nuclear import by β-like importins.F1000prime reports · 2013Review
- Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model.Cellular microbiology · 2012Article
- RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.Developmental biology · 2011Article
- A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.Developmental cell · 2011Article
- A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila.Brain research · 2010Article
- Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells.PloS one · 2010Article
- C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Identification of novel regulators of atonal expression in the developing Drosophila retina.Genetics · 2008Article
- How Drosophila melanogaster Forms its Mechanoreceptors.Current genomics · 2008Article
- Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.Molecular biology of the cell · 2007Article
- Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development.Developmental biology · 2007Article
- Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In proneural groups of cells in the morphogenetic furrow of the developing Drosophila eye phosphorylated mitogen activated protein kinase (MAPK) antigen is held in the cytoplasm for hours. We have developed a reagent to detect nuclear MAPK non-antigenically and report our use of this reagent to confirm that MAPK nuclear translocation is regulated by a second mechanism in addition to phosphorylation. This "cytoplasmic hold" of activated MAPK has not been observed in cell culture systems. We also show that MAPK cytoplasmic hold has an essential function in vivo: if it is overcome, developmental patterning in the furrow is disrupted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.