ArticleNeurotoxicity research1999
Management of oxidative stress in the CNS: the many roles of glutathione.
Article in Neurotoxicity research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed.
- Article
- Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway.Neurochemical research · 2017Article
- Glutamate receptor-like channel3.3 is involved in mediating glutathione-triggered cytosolic calcium transients, transcriptional changes, and innate immunity responses in Arabidopsis.Plant physiology · 2013Article
- Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Article
- MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils.Molecular and cellular biochemistry · 2010Article
- Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.Journal of virology · 2004Article
- Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses.Brain pathology (Zurich, Switzerland) · 2000Review
- Review of apoptosis vs. necrosis of substantia nigra pars compacta in Parkinson's disease.Neurotoxicity research · 2000Article
- Nutritional regulation of glutathione in stroke.Neurotoxicity research · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An outline is given of mechanisms that generate oxidative stress and inflammation. Considered are the metabolic mechanisms that give rise to peroxides, the source of strong oxidants; the production of dicarbonyls that interact with macromolecules to form advanced glycation endproducts; and the role that activation of the transcription factor NF(Kappa)B has in the expression of pro-inflammatory genes. Management of oxidative stress is considered by outlining the central role of reduced glutathione (GSH) in peroxide scavenging, dicarbonyl scavenging and activation of NF(Kappa)B. Cellular GSH levels are dictated by the balance between consumption, oxidation of GSH, reduction of oxidized-glutathione, and synthesis. The rate-limiting enzyme in GSH synthesis is L-gamma-glutamyl-L-cysteine synthase, a phase II enzyme. Phase II enzyme inducers are found in many fruits and vegetables. It is suggested that dietary phase II enzyme inducers be investigated for their potential for preventing or retarding the development of degenerative diseases that have an underlying oxidative stress and inflammatory component.
Identifiers
12835108What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.