ArticleBiophysical journal1992
Ion channels on synaptic vesicle membranes studied by planar lipid bilayer method.
Article in Biophysical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- The synaptic vesicle protein synaptophysin: purification and characterization of its channel activity.Biophysical journal · 2002Article
- Ca(2+)-regulated, neurosecretory granule channel involved in release from neurohypophysial terminals.The Journal of physiology · 2002Article
- ATP-sensitive anion channel from rat brain synaptosomal membranes incorporated into planar lipid bilayers.Biophysical journal · 1997Article
- Ion channels from synaptic vesicle membrane fragments reconstituted into lipid bilayers.Biophysical journal · 1996Article
- The non-specific ion channel in Torpedo ocellata fused synaptic vesicles.The Journal of physiology · 1995Article
- Evidence for a K+ channel in bovine chromaffin granule membranes: single-channel properties and possible bioenergetic significance.European biophysics journal : EBJ · 1994Article
- Making synaptic vesicles fuse with lipid bilayers.Biophysical journal · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An anion selective channel and three types of cation selective channels were found in planar lipid bilayers incorporating synaptic vesicles from rat brains. In asymmetric KCl solutions (cis: 300 mM/trans: 150 mM), the anion selective channel showed a single-channel conductance of 94 pS and was inactivated by negative voltages and by 4-acetoamido-4'-isothiocyanostilbene-2,2'-disulfonic acid disodium salt (SITS). In the same solution, single-channel conductances of three types of cation selective channels were 250 pS (Type 1), 248 pS (Type 2), and 213 pS (Type 3), respectively. These channels resembled one another in single-channel conductances but were different in gating behaviors. Type 1 channel, which was most frequently observed, had a remarkable subconducting state (175 pS). Type 2 channel had a flickering state that increased as the potential became more positive, and a long inactive state that increased as the potentials were more negative. Type 3 channel, which was also sensitive to the potentials, had the open-channel probability increased as the potential became more positive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.