ArticleThorax2003
Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles.
Article in Thorax, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review.Intensive care medicine experimental · 2026Review
- LPS Response Is Impaired by Urban Fine Particulate Matter.International journal of molecular sciences · 2022Article
- Diesel Exhaust Particulates Enhances Susceptibility of LPS-Induced Acute Lung Injury through Upregulation of the IL-17 Cytokine-Derived TGF-βBiomolecules · 2021Article
- Air pollution impairs recovery and tissue remodeling in a murine model of acute lung injury.Scientific reports · 2020Article
- Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes.American journal of respiratory and critical care medicine · 2019Article
- Fine particulate matter in acute exacerbation of COPD.Frontiers in physiology · 2015Review
- Nanotoxicity overview: nano-threat to susceptible populations.International journal of molecular sciences · 2014Review
- Article
- Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines.The American journal of pathology · 2011Article
- Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases.Environmental health and preventive medicine · 2011Review
- Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization.PloS one · 2011Article
- Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years.American journal of respiratory and critical care medicine · 2009Article
- Trial to evaluate effects of ambient particulate matter on health: A preliminary study using two-dimensional gel electrophoresis.Environmental health and preventive medicine · 2007Article
- Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseases.Journal of clinical biochemistry and nutrition · 2007Article
- Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice.Environmental health perspectives · 2006Article
- Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice.Environmental health perspectives · 2006Article
- Protective role of metallothionein in acute lung injury induced by bacterial endotoxin.Thorax · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiesel exhaust particles (DEP) synergistically aggravate acute lung injury related to lipopolysaccharide (LPS) in mice, but the components in DEP responsible for this have not been identified. A study was undertaken to examine the effects of the organic chemicals (DEP-OC) and residual carbonaceous nuclei (washed DEP) derived from DEP on LPS related lung injury.
methodsICR mice were divided into experimental groups and vehicle, LPS, washed DEP, DEP-OC, washed DEP+LPS, and DEP-OC+LPS were administered intratracheally. The cellular profile of the bronchoalveolar lavage (BAL) fluid, pulmonary oedema, lung histology, and expression of proinflammatory molecules and Toll-like receptors in the lung were evaluated.
resultsBoth DEP-OC and washed DEP enhanced the infiltration of neutrophils into BAL fluid in the presence of LPS. Washed DEP combined with LPS synergistically exacerbated pulmonary oedema and induced alveolar haemorrhage, which was concomitant with the enhanced lung expression of interleukin-1beta, macrophage inflammatory protein-1alpha, macrophage chemoattractant protein-1, and keratinocyte chemoattractant, whereas DEP-OC combined with LPS did not. Gene expression of Toll-like receptors 2 and 4 was increased by combined treatment with washed DEP and LPS. The enhancement effects of washed DEP on LPS related changes were comparable to those of whole DEP.
conclusionsThese results suggest that the residual carbonaceous nuclei of DEP rather than the extracted organic chemicals predominantly contribute to the aggravation of LPS related lung injury. This may be mediated through the expression of proinflammatory cytokines, chemokines, and Toll-like receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.