ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression.iScience · 2024Article
- Fibroblast-derivedeLife · 2022Article
- Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle.Cellular and molecular life sciences : CMLS · 2014Review
- Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.Developmental biology · 2011Article
- Article
- Abnormal development of the neuromuscular junction in Nedd4-deficient mice.Developmental biology · 2009Article
- Evidence for muscle-dependent neuromuscular synaptic site determination in mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.BMC developmental biology · 2008Article
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism.Journal of neurobiology · 2006Article
- Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.Molecular and cellular biology · 2005Article
- An initial blueprint for myogenic differentiation.Genes & development · 2005Article
- A selective role for MRF4 in innervated adult skeletal muscle: Na(V) 1.4 Na+ channel expression is reduced in MRF4-null mice.Gene expression · 2005Article
- Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts.Respiratory research · 2004Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Myogenic regulatory factors (MRFs), muscle-specific transcription factors, are implicated in the activity-dependent regulation of nicotinic acetylcholine receptor (AChR) subunit genes. Here we show, with immunohistochemistry, Western blotting, and electron microscopy that MyoD, a member of the MRF family, also plays a role in fetal synapse formation. In the diaphragm of 14.5 d gestation (E14.5) wild-type and MyoD-/- mice, AChR clusters (the formation of which is under a muscle intrinsic program) are confined to a centrally located endplate zone. This distribution persists in wild-type adult muscles. However, beginning at E15.5 and extending to the adult, innervated AChR clusters are distributed all over the diaphragm of MyoD-/- mice, extending as far as the insertion of the diaphragm into the ribs. In wild-type muscle, motor axons terminate on clusters adjacent to the main intramuscular nerve; in MyoD-/- muscle, axonal bundles form extensive secondary branches that terminate on the widely distributed clusters. The number of AChR clusters on adult MyoD-/- and wild-type diaphram muscles is similar. Junctional fold density is reduced at MyoD-/- endplates, and the transition from the fetal (alpha, beta, gamma, delta) to adult-type (alpha, beta, delta, epsilon) AChRs is markedly delayed. However, MyoD-/- mice assemble a complex postsynaptic apparatus that includes muscle-specific kinase (MuSK), rapsyn, erbB, and utrophin.
Indexed as
Identifiers
12832540PMC6741161W1916270054What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.