ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Unraveling Neurodegeneration: Common Molecular Mechanisms and Novel Therapeutic Concepts in Major Neurodegenerative Disorders.Brain and behavior · 2026Review
- When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury.Frontiers in systems neuroscience · 2026Review
- Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism.Brain communications · 2026Review
- LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons.Experimental neurology · 2020Article
- What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury.Journal of neurotrauma · 2017Review
- Article
- NSAIDs modulate GABA-activated currents via CaExperimental and therapeutic medicine · 2016Article
- Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells.Frontiers in molecular neuroscience · 2012Article
- SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.The Journal of cell biology · 2008Article
- Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm.Pathophysiology : the official journal of the International Society for Pathophysiology · 2007Article
- Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Roles of volume-sensitive chloride channel in excitotoxic neuronal injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AMPA receptor-mediated excitotoxicity has been implicated in the pathogenesis of stroke, neurotrauma, epilepsy, and many neurodegenerative diseases such as motoneuron disease. We studied the role of Cl- in AMPA receptor-mediated Ca2+-dependent excitotoxicity in cultured rat spinal motoneurons. Using the gramicidin perforated patch-clamp technique, the intracellular Cl- concentration could be calculated from the reversal potential of the GABA-induced current. The membrane depolarization caused by AMPA receptor stimulation resulted in Cl- influx through 5-nitro-2(3-phenylpropyl-amino) benzoic acid- and niflumic acid-sensitive Cl- channels. Cl- influx during AMPA receptor stimulation aggravated excitotoxic motoneuron death by two mechanisms: an increase of AMPA receptor conductance and an elevation of the Ca2+ driving force through a partial repolarization. The Cl- influx during AMPA receptor stimulation was enhanced by coadministration of GABA. This resulted in an increased Ca2+ influx and an enhanced cell death, suggesting that concomitant GABAergic stimulation may aggravate excitotoxic motoneuron death.
Indexed as
Identifiers
12832516PMC6741175What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.