ArticleEuropean journal of clinical pharmacology2003
Placebo effect and placebos: what are we talking about? Some conceptual and historical considerations.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Frequency and circumstances of placebo use in clinical practice--a systematic review of empirical studies.BMC medicine · 2010Pooled it
- A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials.European journal of clinical pharmacology · 2006Pooled it
- Melatonin for sedative withdrawal in older patients with primary insomnia: a randomized double-blind placebo-controlled trial.British journal of clinical pharmacology · 2014Trial
- Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial.PLoS neglected tropical diseases · 2012Trial
- The role of superstition in the placebo effect on memory performance.Cognitive processing · 2021Article
- Common Limitations and Challenges of Dietary Clinical Trials for Translation into Clinical Practices.International journal of endocrinology and metabolism · 2021Review
- Medical practice and placebo response: an inseparable bond?Wiener klinische Wochenschrift · 2020Review
- Article
- Causal diagrams, the placebo effect, and the expectation effect.International journal of general medicine · 2013Article
- [Clinical significance of the placebo effect].Der Anaesthesist · 2008Review
- Optimizing the pharmacological component of integrated balance therapy.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placebos and the placebo effect have always been present in medical history. However, they have not received the same consideration over the years. Somewhere between art and science, the placebo historical references come from Ancient Egypt and cross over the major civilisations, beliefs and scientific advances. The use of placebo as a methodological tool has assumed a leading role in the last 50 years and has become an important role in controlled clinical trials, the main element of the "evidence-based-medicine" paradigm. Knowledge of the conceptual and historical considerations of placebo may help to understand its role in medical practice. Even without a consensual definition, and assuming that the placebo effect does not seem to be fully dependent on a placebo administration, one issue seems unquestionable: the placebo effect is present in clinical practice and in clinical trials, no matter which name we choose to call it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.