ArticleJournal of virology2003
Infectivity and replication capacity of drug-resistant human immunodeficiency virus type 1 variants isolated during primary infection.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.PLoS pathogens · 2020Article
- The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa.BMC infectious diseases · 2017Article
- Viral envelope is a major determinant of enhanced fitness of a multidrug-resistant HIV-1 variant.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients.Retrovirology · 2012Article
- HIV-1 clade B and C isolates exhibit differential replication: relevance to macrophage-mediated neurotoxicity.Neurotoxicity research · 2011Article
- Prevalence of primary resistance at baseline in acutely and recently infected subjects enrolled in AIDS clinical trials group protocol 371.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Minority variants of drug-resistant HIV.The Journal of infectious diseases · 2010Review
- The localization of APOBEC3H variants in HIV-1 virions determines their antiviral activity.Journal of virology · 2010Article
- Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in China.Virology journal · 2009Article
- Transmission cluster of multiclass highly drug-resistant HIV-1 among 9 men who have sex with men in Seattle/King County, WA, 2005-2007.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- In vitro characterization of multidrug-resistant HIV-1 isolates from a recently infected patient associated with dual tropism and rapid disease progression.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- Clinical significance of human immunodeficiency virus type 1 replication fitness.Clinical microbiology reviews · 2007Review
- Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification.PLoS pathogens · 2005Article
- Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture.Antimicrobial agents and chemotherapy · 2004Article
- Density-dependent selection in vesicular stomatitis virus.Journal of virology · 2004Article
- The population genetics and evolutionary epidemiology of RNA viruses.Nature reviews. Microbiology · 2004Review
- Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors.Journal of virology · 2004Article
- Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.Journal of virology · 2004Article
- The causes and consequences of HIV evolution.Nature reviews. Genetics · 2004Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
It is believed that replication capacity is an important determinant of human immunodeficiency virus type 1 (HIV-1) pathogenicity and transmissibility. To explore this, we conducted a comprehensive analysis of the replication properties of nine drug-resistant and nine drug-susceptible viral isolates derived from patients with primary HIV-1 infection. Viral isolates were tested for single-cycle infectivity in the GHOST cell line. The infectivity of isolates carrying resistance-associated mutations was significantly higher than that of drug-susceptible isolates. Additionally, the growth kinetics of these isolates were determined in CD4+ T lymphocytes. Drug-resistant isolates replicated as well as drug-susceptible viruses. Insertion of the resistance-conferring regions into an NL4-3-based molecular background resulted in chimeras that displayed a modest but significant reduction in replication capacity compared to the drug-susceptible chimeric viruses. Of note, two multidrug-resistant isolates and one protease inhibitor-resistant isolate displayed higher rates of infectivity and growth kinetics than the other drug-resistant or drug-susceptible isolates. These distinct replicative features, however, were not seen in the corresponding chimeras, indicating that changes within the C-terminal region of Gag as well as within the protease and reverse transcriptase genes contribute to but are not sufficient for the level of compensatory adaptation observed. These findings suggest that some drug-resistant viruses isolated during primary infection possess unique adaptive changes that allow for both high viral replication capacity and resistance to one or more classes of antiretroviral drugs. Further studies are needed to elucidate the precise regions that are essential for these characteristics.
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