ArticleBiophysical journal2003
Order, disorder, and perturbations in actin-aldolase rafts.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Electron cryo-tomography of vestibular hair-cell stereocilia.Journal of structural biology · 2019Article
- Identification of interfaces involved in weak interactions with application to F-actin-aldolase rafts.Journal of structural biology · 2018Article
- Article
- Spatial localisation of actin filaments across developmental stages of the malaria parasite.PloS one · 2012Article
- How to make a curved Drosophila bristle using straight actin bundles.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
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2 authors.
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Abstract
Actin-aldolase rafts provide insights into the use of rafts as models for three-dimensional actin bundles. Although aldolase has three twofold axes, filaments in actin-aldolase rafts were not strictly related by a twofold axis. Interfilament angles were on average +15 degrees off the expected 180 degrees, and most rafts appeared handed; that is, rows of cross-bridges were tilted in a clockwise direction off the perpendicular. We can account for both the deviation of the angle from 180 degrees and the handedness of the rafts by a steric constraint due to the lipid layer. We further found that the axial spacings of cross-bridges varied significantly from raft to raft. We suggest that this difference arises from variations in the twist of the filaments that nucleate raft formation; that is, filaments added to a raft adopt the symmetry of those in the raft. We conclude that the organization of filaments in rafts can be modulated by outside factors such as the lipid layer and that the variable twist of filaments in the nucleating core of the raft are imposed on all the filaments in the raft. These results provide a measure of the potential for polymorphism in actin assemblies.
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