ArticleBiophysical journal2003
Two adaptation processes in auditory hair cells together can provide an active amplifier.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Neural control and innate self-tuning of the hair cell's active process.Biophysical journal · 2024Article
- Time scales of adaptation to context in horizontal sound localization.The Journal of the Acoustical Society of America · 2023Article
- Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex.Nature communications · 2020Article
- Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea.eLife · 2019Article
- Homeostatic enhancement of sensory transduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Frequency locking in auditory hair cells: Distinguishing between additive and parametric forcing.Europhysics letters · 2016Article
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Phase-locked spiking of inner ear hair cells and the driven noisy Adler equation.Interface focus · 2014Article
- Olfactory coding in the insect brain: data and conjectures.The European journal of neuroscience · 2014Review
- Low frequency entrainment of oscillatory bursts in hair cells.Biophysical journal · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
- Mode-locking dynamics of hair cells of the inner ear.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- A mean-field approach to elastically coupled hair bundles.The European physical journal. E, Soft matter · 2012Article
- Dynamics of freely oscillating and coupled hair cell bundles under mechanical deflection.Biophysical journal · 2012Article
- The diverse effects of mechanical loading on active hair bundles.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Spontaneous oscillations, signal amplification, and synchronization in a model of active hair bundle mechanics.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Distribution of frequencies of spontaneous oscillations in hair cells of the bullfrog sacculus.Biophysical journal · 2009Article
- Frequency clustering in spontaneous otoacoustic emissions from a lizard's ear.Biophysical journal · 2008Article
- The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells.Biophysical journal · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hair cells of the vertebrate inner ear convert mechanical stimuli to electrical signals. Two adaptation mechanisms are known to modify the ionic current flowing through the transduction channels of the hair bundles: a rapid process involves Ca(2+) ions binding to the channels; and a slower adaptation is associated with the movement of myosin motors. We present a mathematical model of the hair cell which demonstrates that the combination of these two mechanisms can produce "self-tuned critical oscillations", i.e., maintain the hair bundle at the threshold of an oscillatory instability. The characteristic frequency depends on the geometry of the bundle and on the Ca(2+) dynamics, but is independent of channel kinetics. Poised on the verge of vibrating, the hair bundle acts as an active amplifier. However, if the hair cell is sufficiently perturbed, other dynamical regimes can occur. These include slow relaxation oscillations which resemble the hair bundle motion observed in some experimental preparations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.