ArticleBiophysical journal2003
A model of phosphofructokinase and glycolytic oscillations in the pancreatic beta-cell.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 89 citations in OpenAlex.
- The Dual Anaplerotic Model (DAM): Integral Roles of Pyruvate Carboxylase and the GABA Shunt in Beta Cell Insulin Secretion.Life (Basel, Switzerland) · 2026Article
- Multilevel synchronization of humanFrontiers in network physiology · 2023Article
- Synchronization of the Glycolysis Reaction-Diffusion Model via Linear Control Law.Entropy (Basel, Switzerland) · 2021Article
- The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.Scientific reports · 2021Article
- Assessing Different Temporal Scales of Calcium Dynamics in Networks of Beta Cell Populations.Frontiers in physiology · 2021Article
- Article
- Spatiotemporal Modeling of Triggering and Amplifying Pathways in GLP-1 Secreting Intestinal L Cells.Biophysical journal · 2017Article
- Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.Biophysical journal · 2016Article
- Multiplicity of steady states in glycolysis and shift of metabolic state in cultured mammalian cells.PloS one · 2015Article
- Mathematical modeling of heterogeneous electrophysiological responses in human β-cells.PLoS computational biology · 2014Article
- The impact of mathematical modeling on the understanding of diabetes and related complications.CPT: pharmacometrics & systems pharmacology · 2013Article
- Article
- Article
- Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism.PloS one · 2012Article
- Integrating systems biology models and biomedical ontologies.BMC systems biology · 2011Article
- Periodic orbits in glycolytic oscillators: from elliptic orbits to relaxation oscillations.The European physical journal. E, Soft matter · 2011Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Oscillations at odds in the heart.The Journal of general physiology · 2010Article
- Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.Advances in experimental medicine and biology · 2010Review
- Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed a model of the upper part of the glycolysis in the pancreatic beta-cell. The model comprises the enzymatic reactions from glucokinase to glyceraldehyde-3-phosphate dehydrogenase (GAPD). Our results show, for a substantial part of the parameter space, an oscillatory behavior of the glycolysis for a large range of glucose concentrations. We show how the occurrence of oscillations depends on glucokinase, aldolase and/or GAPD activities, and how the oscillation period depends on the phosphofructokinase activity. We propose that the ratio of glucokinase and aldolase and/or GAPD activities are adequate as characteristics of the glucose responsiveness, rather than only the glucokinase activity. We also propose that the rapid equilibrium between different oligomeric forms of phosphofructokinase may reduce the oscillation period sensitivity to phosphofructokinase activity. Methodologically, we show that a satisfying description of phosphofructokinase kinetics can be achieved using the irreversible Hill equation with allosteric modifiers. We emphasize the use of parameter ranges rather than fixed values, and the use of operationally well-defined parameters in order for this methodology to be feasible. The theoretical results presented in this study apply to the study of insulin secretion mechanisms, since glycolytic oscillations have been proposed as a cause of oscillations in the ATP/ADP ratio which is linked to insulin secretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.